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. 2016 Aug;57(8):1423–1434. doi: 10.1194/jlr.M067165

TABLE 2.

Mean transit times, residence times, FCRs, and recycling numbers in neonatal rats in D-VARA and M-VA groups as predicted by the plasma-view model

Treatment Group
Parametersa Oil D-VARA M-VA
t(5), h 0.40 0.24 0.26
t(6), days 1.64 1.14 1.03
T(5,5), days 2.40 0.18 0.06
FCR(5,5), day−1 0.42 5.56 16.7
FCR(5,5), day−1 (after day 8) 14.7 5.56 16.7
ν(5) 144 17 5

The model is shown in Fig. 3. Oil values taken from (13).

a

Parameters shown are: mean transit time [t(5)], or the mean of the time that a retinol molecule spends in compartment 5 (plasma retinol-RBP) during a single transit before leaving reversibly or irreversibly; mean transit time [t(6)], or the mean of the time that a retinol molecule spends in compartment 6 (extravascular tissue retinol) during a single transit before leaving reversibly or irreversibly; mean residence time [T(5,5)], or the average of the distribution of times that a molecule of retinol spends in compartment 5 (plasma retinol-RBP) before it leaves irreversibly; FCR(5,5), or the fraction of the plasma retinol pool that is utilized each day; recycling number [ν(5)], or the average number of times a retinol molecule recycles through compartment 5 (plasma retinol-RBP) before it irreversibly exits from it.

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