TABLE 1.
Basal parameters and plasma and hepatic total cholesterol after 2 weeks of statin treatment
Control | Rosuvastatin | Atorvastatin | Lovastatin | |
BW (g) | 26.9 (25.5–28.4) | 26.7 (26.1–27.1) | 25.6 (24.7–26.1) | 24.4 (23.5–25.1)a |
Food intake (g/day) | 4.3 (3.7–5.0) | 4.3 (3.6–4.8) | 5.4 (4.4–6.5) | 4.1 (3.7–4.6) |
Fecal output (g/day) | 0.77 (0.73–0.83) | 0.85 (0.81–0.85) | 0.79 (0.65–0.89) | 0.60 (0.52–0.75)a |
Liver weight (% of BW) | 4.6 (3.6–5.0) | 4.9 (4.6–5.0) | 4.4 (4.4–4.9) | 5.1 (5.0–5.6)a |
Plasma total cholesterol (mM) | 2.32 (2.03–2.49) | 2.00 (1.86–2.26) | 1.72 (1.38–1.93)a | 1.81 (1.64–1.95)a |
Hepatic total cholesterol (nmol/mg protein) | 29.7 (28.1–31.0) | 29.2 (26.9–31.2) | 31.5 (28.3–34.0) | 38.5 (34.8–41.0)a |
Values are expressed as median with the interquartile range.
P < 0.05 versus control.