Fig. 8.

Effects of Cl-lipids on airway hyperresponsiveness. C57bl/6 male mice were exposed to ethanol (ETOH) (filled square), PA (open triangle), Pald (open diamond), 2-Cl-PA (filled inverted triangle) or 2-Cl-Pald (filled circle) by intranasal administration and basal and methacholine-induced airway resistance (A, B, E) and elastance (C, D, F) determined by Flexivent. For clarity, 2-Cl-PA (A, C, E) and 2-Cl-Pald (B, D, F) are shown on separate panels; ethanol control group is the same on each panel. Data are mean ± SEM (n = 3–4). For (A–D), *P < 0.05 relative to ethanol or ^#P < 0.05 relative to parent fatty acid by two-way repeated measures-ANOVA with Bonferroni post test. For (E, F), *P < 0.05 by one-way ANOVA with Tukey post test.