Table 1.
Expression, Mutations, and Chromosomal Translocations of PcG Genes in Human Cancers
| Subunit | Aberrant Expression | |
|---|---|---|
| Expression | Cancer Type | |
| PRC2 Components | ||
| Ezh2 | overexpression and/or amplification | B cell non-Hodgkin lymphomas,35 bladder cancers,1,5,29,41 breast cancers,2,5,8,15,27 colon cancers,5,22 glioblastoma,5 Hodgkin lymphomas,28 oral cancers,5 liver cancers,33 lung cancers,5 lymphoma,5 mantle cell lymphomas,37 melanomas,2 prostate cancers,2,36 testicular cancers5 |
| Suz12 | overexpression and/or amplification | breast cancers,14 colon cancers,14,42 germinal cell-derived tumors,20 liver cancers,14 lung cancers,20 mantle cell lymphomas,20 melanomas,20 parathyroid and pituitary adenomas20 |
| Pcl3/Phf19 | overexpression | colon cancers,39 skin cancers,39 lung cancers,39 rectal cancers,39 cervical cancers,39 uterus cancers,39 liver cancers39 |
| PRC1 components | ||
| Cbx7 | overexpression | follicular lymphoma32 |
| loss | pancreatic cancers13 | |
| Phc1 | loss of heterozygosity | acute lymphoblastic leukemias34 |
| Phc3 | loss of heterozygosity | Osteosarcomas12,17 |
| Bmi1 | overexpression and/or amplification | acute myeloid leukemias,31 breast cancers,30 gastrointestinal tumors,30 lymphomas,3,30,35 medulloblastomas,18 neuroblastomas,26 lung cancers,38,30 parathyroid and pituitary adenomas30 |
| Pcgf2/Mel18 | loss | cutaneous squamous-cell carcinomas,30 gynecological tumors,30 prostate cancers30,40 |
| Ring1a | loss | clear-cell renal-cell carcinomas,30 testicular germ-cell tumors30 |
| Ring1b | overexpression | bladder cancers,30 breast cancers,30 colon tumors,30 gynecological tumors,30 kidney cancers,30 larynx cancers,30 livers cancers,30 lung cancers,30 lymphomas,30 melanomas,30 pancreas cancers,30 parathyroid and thyroid cancers,30 prostate cancers,30 skin cancers,30 thymus cancers,30 urinary tract cancers30 |
| Subunit | Mutations | |
| Type of Mutation | Cancer Type | |
| PRC2 Components | ||
| Ezh2 | missense | diffuse large B cell lymphomas,23 myelodysplasic/myeloproliferative syndromes10,25 |
| Epc1 | truncation | acute lymphoblastic leukemias24 |
| PRC1 Components | ||
| Phc3 | missense | osteosarcomas9,12 |
| Asxl1 | frameshift, truncation | acute myeloid leukemias,4,7 myelodysplasic/myeloproliferative syndromes4,6,11 |
| Subunit | Chromosomal Translocations | |
| Fusion Gene Partner | Cancer Type | |
| PRC2 Components | ||
| Suz12 | Jazf1 | endometrial stromal sarcomas16,19 |
| Pcl1/Phf1 | Jazf1, Epc1 | endometrial stromal sarcomas21 |
| Epc1 | Asxl2 | acute lymphoblastic leukemias24 |
| PRC1 Components | ||
| Asxl2 | Epc1 | acute lymphoblastic leukemias24 |
See Supplemental Information for detailed numerical references.