Table 4.
Statistical analysis. ROC curve analysis.
| ypCR vs ypPR and ypSD | responders (ypCR, ypPR) vs ypSD | ypSD vs responders (ypCR, ypPR) | ||
|---|---|---|---|---|
| ADC pre-CRT | OCV ADC (×10−3 mm2/s) | 0.8 | 0.9 | 0.9 |
| AUC | 0.793 | 0.718 | 0.718 | |
| Sensitivity% | 100 | 81.82 | 60 | |
| Specificity% | 66.67 | 60 | 81.82 | |
| ADC post-CRT | OCV ADC (×10−3 mm2/s) | 1.3 | 1.1 | 1.1 |
| AUC | 0.763 | 0.77 | 0.77 | |
| Sensitivity% | 60 | 77.27 | 70 | |
| Specificity% | 92.59 | 70 | 77.27 | |
| Δ ADC post−ADC pre | OCV ADC (×10−3 mm2/s) | 0.3 | 0.2 | 0.2 |
| AUC | 0.87 | 0.873 | 0.873 | |
| Sensitivity% | 100 | 72.73 | 100 | |
| Specificity% | 70.37 | 100 | 72.73 | |
ypCR: complete response; ypPR: partial response; ypSD: stable disease; CRT: chemo-radiotherapy; OCV ADC: optimal cut-off ADC value; AUC: area under the ROC curve.