Table 1.

Results of the ANOVAs

Figure 2	A				C
	Factor	F value	D.F.	Sig.	Factor	F value	D.F.	Sig.
	nalmefene	23.13	3, 79	<0.0001	nalmefene	1.09	3, 82	0.36
	days	1.91	3, 237	0.13	days	6.66	1, 82	<0.05
	interaction	1.58	9, 237	0.12	interaction	0.96	3, 82	0.41
	B				D
	Factor	F value	D.F.	Sig.	Factor	F value	D.F.	Sig.
	nalmefene	21.58	3, 81	<0.0001	nalmefene	1.39	3, 81	0.25
	days	1.98	3, 243	0.12	days	6.02	1, 81	<0.05
	interaction	1.26	9, 243	0.26	interaction	0.67	3, 81	0.57
Figure 3	A				C
	Factor	F value	D.F.	Sig.	Factor	F value	D.F.	Sig.
	nalmefene	23.52	3, 80	<0.0001	nalmefene	0.98	3, 83	0.41
	days	1.48	3, 240	0.22	days	4.36	1, 83	<0.05
	interaction	3.44	9, 240	<0.005	interaction	1.44	3, 83	0.24
	B				D
	Factor	F value	D.F.	Sig.	Factor	F value	D.F.	Sig.
	nalmefene	17.98	3, 83	<0.0001	nalmefene	0.81	3, 84	0.49
	days	1.69	3, 249	0.17	days	4.49	1, 84	<0.05
	interaction	3.37	9, 249	<0.005	interaction	1.00	3, 84	0.39
Figure 4	A				B
	Factor	F value	D.F.	Sig.	Factor	F value	D.F.	Sig.
	nalmefene	0.48	3, 36	0.69	nalmefene	2.41	3, 36	0.08
	intervals	287.30	5, 180	<0.0001
	interaction	0.70	15, 180	0.78
	C				D
	Factor	F value	D.F.	Sig.	Factor	F value	D.F.	Sig.
	nalmefene	0.65	3, 37	0.58	nalmefene	0.59	3, 38	0.63
	intervals	261.37	5, 185	<0.0001
	interaction	0.82	15, 185	0.65
Figure 5	A				C
	Factor	F value	D.F.	Sig.	Factor	F value	D.F.	Sig.
	nalmefene	33.51	2, 37	<0.0001	nalmefene	0.11	2, 37	0.9
	EtOH conc.	132.87	2, 74	<0.0001	days	2.45	3, 111	0.07
	interaction	3.77	4, 74	<0.01	interaction	2.81	6, 111	<0.05
	B				D
	Factor	F value	D.F.	Sig.	Factor	F value	D.F.	Sig.
	nalmefene	34.71	2, 37	<0.0001	nalmefene	0.07	2, 37	0.94
	EtOH conc.	2.97	2, 74	0.06	days	3.57	3, 111	<0.05
	interaction	5.35	4, 74	<0.005	interaction	2.48	6, 111	<0.05
Figure 6	A				B
	Factor	F value	D.F.	Sig.	Factor	F value	D.F.	Sig.
	treatment	31.44	3, 36	<0.0001	treatment	5.92	3, 36	<0.005
	days	3.26	3, 108	<0.05	days	5.93	3, 108	<0.005
	interaction	0.88	9, 108	0.54	interaction	2.13	9, 108	<0.05
	D				E
	Factor	F value	D.F.	Sig.	Factor	F value	D.F.	Sig.
	treatment	8.05	3, 39	<0.0001	treatment	0.06	1, 18	0.81
Figure 7	A				B
	Factor	F value	D.F.	Sig.	Factor	F value	D.F.	Sig.
	treatment	5.23	3, 36	<0.005	treatment	24.36	3, 36	<0.0001
	days	1.75	3, 108	0.16	intervals	158.6	5, 180	<0,0001
	interaction	0.70	9, 108	0.71	interaction	14.42	15, 180	<0.0001
Figure 8	Blood
	Factor	F value	D.F.	Sig.
	Hdac	4.42	10, 264	<0.0001
	treatment	64.31	2, 264	<0.0001
	interaction	1.51	20, 264	1.51