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. Author manuscript; available in PMC: 2016 Aug 26.
Published in final edited form as: Oncogene. 2016 Jan 25;35(34):4509–4517. doi: 10.1038/onc.2015.510

Figure 5.

Figure 5

p53 and p73-associated apoptotic signals are enhanced in CD4+ T cells of HBZ-Tg mice. (a) The expression of proapoptotic p53/p73 target genes in CD4+ T cells from non-Tg (n=4) and HBZ-Tg (n=4) mice was measured by qPCR. (b) Splenocytes from non-Tg (n=4) and HBZ-Tg (n=4) mice were treated with or without PFT-α for 30 min and then irradiated as indicated. The percentage of apoptotic cells in the CD4+ fraction was measured by Annexin V staining. Two independent experiments were performed and representative data are shown. Statistical significance was determined by the two-tailed paired Student's t-test. Asterisks indicate the statistical significance as follows: *P < 0.05; **P < 0.01; ***P < 0.001.