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. Author manuscript; available in PMC: 2016 Sep 22.
Published in final edited form as: Oncogene. 2016 Jan 25;35(35):4633–4640. doi: 10.1038/onc.2015.527

Figure 6. HER2-WASF3 signaling is critical for metastasis of breast cancer cells.

Figure 6

In vitro invasion assays show that invasion potential of MCF7 cells that overexpress either WASF3 or HER2 is slightly increased but a more significant increase in invasion levels was seen when both genes were overexpressed (a). When HER2 is expressed in WASF3-overexpressing MCF7 cells, enhanced WASF3 phospho-activation is seen, but this activation is suppressed following Herceptin treatment (b). In the experimental metastasis assay in SCID/NOD mice, expression of WASF3 and HER2 together leads to increased levels of metastasis to the lungs (arrows) which is not seen when either of these genes is expressed alone (c). * p<0.05, ** p<0.01; Student’s t-test.