Table 2.
Association of prolonged postoperative care unit stay due to morphine induced respiratory depression with polymorphisms in an identified critical region of ABCC3 gene
| Illumina ID | rs# | Location | Risk allele (%) | Protective allele (%) | P value association | OR (95% CI) | Putative function/ RegulomeDB score | |
|---|---|---|---|---|---|---|---|---|
| Prolonged PACU Stay due to RD | kgp9079579 | rs35364174 | 48731392 | G (0.497) | A (0.503) | 0.0496 | 1.80 (1.00, 3.24) | Intron/5 |
| rs4148412 | 48733815 | A (0.382) | G (0.618) | 0.0061 | 2.36 (1.28, 4.37) | Intron/5 | ||
| rs739923 | 48735774 | G (0.750) | A (0.250) | 0.0050 | 3.70 (1.47, 9.09) | Intron/4 | ||
| rs733392 | 48736403 | G (0.756) | A (0.244) | 0.0239 | 2.63 (1.14, 5.88) | Intron/5 | ||
| rs1978153 | 48737861 | C (0.627) | G (0.373) | 0.0152 | 2.27 (1.18, 4.35) | Intron/2b | ||
| kgp388163 | rs2301837 | 48738266 | G (0.905) | A (0.095) | 0.4262 | 1.56 (0.84, 4.55) | intron | |
| kgp3814620 | rs7216383 | 48739543 | A (0.709) | G (0.291) | 0.0316 | 2.22 (1.08, 4.76) | Intron/4 | |
| kgp2507665 | rs61479331 | 48740116 | A (0.729) | C (0.271) | 0.0524 | 2.08 (0.99, 4.35) | Intron/3a | |
| rs16949202 | 48743275 | A (0.867) | G (0.133) | 0.8366 | 1.10 (0.46, 2.63) | intron | ||
| kgp12280761 | rs886493 | 48744612 | C (0.535) | A (0.465) | 0.0134 | 2.27 (1.18, 4.35) | Intron/5 |
Note: Effects were shown as odds ratio (OR) and 95% CI for prolonged postoperative care unit (PACU) stay due to respiratory depression (RD) in the tonsillectomy cohort. OR indicated the odds ratio when minor allele (races combined) increased by one copy. Putative functional consequences of SNPs above have been also assessed using RegulomeDB (http://regulome.stanford.edu/index), with scores ranging from 1 (highly likely functional, through 2a/b (likely to affect binding of regulatory factors to DNA), to 5/6 (unlikely regulating binding).