Table 4.

Power(%), Scenario 2: Survival and ALSFRS; $T_O^U=\mathit{\text{Proposed O'Brien test}}$, $T_O^{U,\mathit{\text{Ad}}}=\mathit{\text{Proposed Adaptive O'Brien test}}$, $T_O^{U,\mathit{\text{Opt}}}=\mathit{\text{Optimally Weighted O'Brien Test}}$, $T_{\mathit{\text{FS}}}^U=\mathit{\text{Proposed Finkelstein-Schoenfeld}}(\mathit{\text{FS}})\mathit{\text{test}}$, $T_{\mathit{\text{FS}}}^{U,\mathit{\text{Ad}}}=\mathit{\text{Proposed Adaptive FS test}}$, $T_{\mathit{\text{FS}}}^{U,\mathit{\text{Opt}}}=\mathit{\text{Optimally Weighted FS Test}}$.

Effect Size (Survival,ALS)	No. Strata	n	m	$T_O^U$	$T_O^{U,\mathit{\text{Ad}}}$	$T_O^{U,\mathit{\text{Opt}}}$	$T_{\mathit{\text{FS}}}^U$	$T_{\mathit{\text{FS}}}^{U,\mathit{\text{Ad}}}$	$T_{\mathit{\text{FS}}}^{U,\mathit{\text{Opt}}}$
Moderate,Mild	2	50	50	45.7	48.6	59.6	48.1	49.2	59.6
		100	100	73.9	78.9	87.2	77.8	79.4	87.4
	4	25	25	47.0	49.3	58.9	49.2	48.5	58.9
		50	50	74.6	78.8	87.0	77.6	78.2	87.0
Strong,Mild	2	30	30	45.4	55.5	70.8	47.7	56.0	70.8
		60	60	75.2	85.7	95.3	78.1	86.7	95.3
	4	15	15	47.1	59.0	73.4	50.8	58.8	73.4
		30	30	76.1	87.2	95.1	78.4	87.0	95.1
Mild,Moderate	2	50	50	57.3	57.9	65.8	52.9	51.5	59.1
		100	100	85.0	86.0	91.5	80.8	78.3	86.0
	4	25	25	55.9	56.7	65.0	52.1	48.1	58.8
		50	50	86.6	86.7	92.0	82.9	77.9	87.5
Mild,Strong	2	25	25	53.7	58.5	70.2	50.0	51.1	62.4
		50	50	83.3	88.3	94.5	78.7	82.1	90.3
	4	15	15	62.9	67.1	79.2	57.8	58.3	71.3
		25	25	83.6	89.3	94.3	79.8	80.8	89.8
Moderate,None	2	50	50	22.0	38.7	63.7	31.3	44.4	63.7
		100	100	38.9	67.1	89.5	55.3	74.0	89.5
	4	25	25	23.7	44.0	61.9	33.3	46.9	61.9
		50	50	39.8	72.1	89.7	56.4	76.7	89.7
None,Moderate	2	50	50	30.0	45.5	65.1	20.6	35.6	62.9
		100	100	53.9	76.8	92.1	37.2	65.6	90.9
	4	25	25	29.8	49.5	66.5	20.9	40.1	64.4
		50	50	54.6	79.0	91.9	37.2	67.6	90.8
Moderate,Moderate	2	30	30	50.7	47.0	51.0	49.6	44.9	49.5
		60	60	80.0	76.9	80.1	78.6	S74.4	78.6
	4	15	15	50.3	45.2	50.3	48.9	41.9	48.9
		30	30	80.2	75.0	80.2	78.5	69.7	78.3