Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jul 26;4:24. doi: 10.1186/s40635-016-0095-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

PMC Copyright notice

Fig. 3 — Oxygen consumption rates (OCR) were measured in the Seahorse Instrument and examples are shown from mitochondria harvested from an animal in the septic control group (panel a) in a non-septic control dog (panel b) in the norepinephrine (NE) septic group (panel c) and in the gentisic septic group (panel d) under different metabolic conditions. In each experiment, we obtained two measurements in each condition and the average of the two conditions was obtained. In panel a basal OCR was slightly low in the animal in the septic control group as compared with the non septic control group. When adenosine diphosphate (ADP) was added to the preparation, OCR rate in the septic animal in panel A was not different from the animal in the non-septic control group (panel b). However, the response to FCCP (carbonyl cyanide p-triflouromethoxy-phenylhydrazone) in the animal in the septic control group (panel a) was attenuated as compared with the animal in the non-septic control group (panel b). With norepinephrine treatment, there was a restoration in the response to FCCP in the NE septic group (panel c). In the animal in the gentisic septic group, there was a large response in OCR to ADP which nearly equaled the response to FCCP (panel d)