Fig. 4.

Mean oxygen consumption rates (OCR) under the different metabolic conditions are shown for the five groups. In panel a basal OCR in the septic control group was significantly less than that measured in the gentisic septic group. In panel b coupled respiration in the gentisic septic group was significantly greater than the other groups. In panel c uncoupled (maximal) OCR in the septic control group decreased as compared with the other groups in which we used a FCCP of 4 μM (i.e., maximal) in the analysis. In panel d spare respiratory capacity was decreased in the septic control group as compared with the other groups. Spare respiratory capacity was calculated from the difference between uncoupled and basal respiration (see text for Discussion). Statistical analyses included a one way analysis of variance and Student Newman Keuls (SNK) multiple comparison multiple comparison test