Table 3.
Mutagenicity of benfuracarb towards S. typhimurium TA98 and TA100 strain with or without metabolic activation
| Agent | Amount (µg/plate) | Number of his+ revertants/plate mean ± SD* | |||
|---|---|---|---|---|---|
| TA98 | TA100 | ||||
| −S9 | +S9 | −S9 | +S9 | ||
| Benfuracarb | 100 | 34.00 ± 3.24 | 46.80 ± 4.38 | 117.40 ± 8.65 | 175.40 ± 13.07 |
| 50 | 31.80 ± 2.77 | 45.60 ± 3.78 | 110.80 ± 7.56 | 159.20 ± 5.97 | |
| 25 | 31.40 ± 5.41 | 45.40 ± 2.30 | 107.20 ± 8.47 | 134.00 ± 7.21 | |
| 12.5 | 30.80 ± 2.17 | 43.00 ± 2.45 | 99.40 ± 2.88 | 134.40 ± 18.53 | |
| 6.25 | 29.00 ± 2.24 | 40.00 ± 7.84 | 97.80 ± 11.76 | 132.80 ± 2.77 | |
| Negative Control (DMSO) | 100 | 29.00 ± 2.83 | 42.00 ± 3.67 | 92.00 ± 3.74 | 128.80 ± 2.79 |
| SA | 10 | 2,722.40 ± 80.46* | |||
| 2AA | 5 | 2,189.00 ± 99.72* | |||
| 2AF | 200 | 963.00 ± 23.28* | |||
| NPD | 200 | 1,287.00 ± 46.73* | |||
SD standard deviation, SA sodium azide, 2AA 2-aminoanthracene, 2AF 2-aminofluorene, NPD 4-nitro-o-phenylenediamine
* Means statistically significant at the level of 0.05 (Dunnett’s t test, 2-sided)