Table 3.
Summary of scores for each condyle according to the treatment applied
| 6 months | 12 months | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Controls | L | F58l | S | F64ra | F64ra | L | F44r | F44r | S | F59l | F52l |
| 12 | n.d. | n.d. | 7 | 8 | 8 | 13 | |||||
| Hyaline | n.d. | n.d | Mixed | Hyaline | Mixed | Mixed | |||||
| ASC-S | F57l | F63r | F58r | F52l | F61r | F59r | |||||
| 8 | 3 | 7 | 9 | 9 | 7 | ||||||
| Mixed | Mixed | Mixed | Mixed | Mixed | Mixed | ||||||
| BM-MSC-S | F57r | F57r | F58l | F63l | F64la | F52r | F59l | F44l | F61l | ||
| 7 | 4 | 4 | 3 | n.d. | 10 | 8 | 10 | 17 | |||
| Mixed | Mixed | Mixed | Mixed | n.d. | Hyaline | Mixed | Hyaline | Hyaline | |||
| Chond-S | F57l | F63l | F63r | F58r | F64la | F52r | F61l | F61r | F59r | F44l | |
| 4 | 8 | 4 | 11 | n.d. | 10 | 11 | 7 | 9 | 8 | ||
| Mixed | Mixed | Mixed | Hyaline | n.d. | Hyaline | Hyaline | Mixed | Mixed | Hyaline | ||
This summary includes histological evaluation (maximum score = 18 points) and the overall classification of the type of new tissue generated in the defect (either hyaline or mixed hyaline/fibrocartilage). The code used for animal identification corresponds to animal number (i.e.: F6) followed by the r (right) or l (left) knee (i.e.: F6r), according to the experimental groups described in Table 1
ASC-S scaffold seeded with adipose tissue-derived MSC, BM-MSC-S scaffold seeded with bone marrow-derived MSC, Chond-S scaffold seeded with progenitor cells derived from cartilage tissue, S cell-free scaffold, L untreated lesion, nd not determined
aAnimal F64 was found dead at month 4 after treatment