Table 3. Brain regions with significant correlations between GMV and clinical parameters in patients with unilateral MTLE.
| Group | Location | Peak level | MNI coordinates (mm) | |||||
|---|---|---|---|---|---|---|---|---|
| T | KE | PFDR | x | y | z | |||
| RMTLE | ||||||||
| Duration of epilepsy (-) | Middle frontal gyrus | R | 4.03 | 3.55 | <0.001 | 29 | -1 | 59 |
| Precentral gyrus | R | 3.62 | 3.25 | 0.001 | 48 | 15 | 9 | |
| Parietal lobe (subgyral) | L | 3.49 | 3.16 | 0.001 | -32 | -45 | 49 | |
| Seizure frequency (-) | Temporal lobe (subgyral) | R | 3.77 | 3.36 | <0.001 | 46 | -33 | -5 |
| Seizure onset age (+) | Superior frontal gyrus | L | 3.69 | 3.30 | <0.001 | -9 | -7 | 67 |
| Middle temporal gyrus | R | 4.16 | 3.64 | <0.001 | 37 | -2 | -35 | |
| Parahippocampal gyrus | L | 3.99 | 3.52 | <0.001 | -23 | -2 | -27 | |
| Medial globus pallidus | L | 3.85 | 3.42 | <0.001 | -17 | -7 | -6 | |
| Cuneus | L | 3.84 | 3.41 | <0.001 | -23 | -88 | 33 | |
| LMTLE | ||||||||
| Seizure onset age (+) | Occipital lobe | R | 4.18 | 3.65 | <0.001 | 2 | -71 | 0 |
| Extranuclear | R | 3.82 | 3.40 | <0.001 | 34 | -2 | 3 | |
| Insula | L | 3.56 | 3.20 | 0.001 | -35 | 2 | -5 | |
| Febrile seizure (-) | Middle frontal gyrus | L | 3.77 | 3.36 | <0.001 | -38 | 41 | 21 |
| Superior temporal gyrus | R | 3.47 | 3.14 | 0.001 | 48 | -33 | 9 | |
+: positive correlation, -: negative correlation, GMV: gray matter volume, L: left, MNI: Montreal neurological institute, MTLE: mesial temporal lobe epilepsy, T: test statistics, R: right, UNC: uncorrected, ZE: z-score (the number of standard deviations away from the mean).