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. 2016 Jul 26;10:374. doi: 10.3389/fnhum.2016.00374

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Copyright © 2016 Cacciola, Milardi, Anastasi, Basile, Ciolli, Irrera, Cutroneo, Bruschetta, Rizzo, Mondello, Bramanti and Quartarone.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anatomical relations of cortico-nigral probabilistic fiber tracking. In particular, panel (A) depicts left cortico-nigral pathway in a posterior parasagittal view; panel (B) shows bilateral cortico-nigral tract in posterior coronal view and panel (C) shows right cortico-nigral tract in posterior parasagittal view. 3D-rendered models of basal ganglia are shown to better illustrate anatomical relation: SN is shown colored in blue, caudate nucleus in dark green, thalamus in pale purple, putamen in pink, pallidum in light blue, STN in yellow and RN in brown. Cortico-nigral tracts runs mainly through internal capsule, avoiding thalamus, putamen and globus pallidus, and reach SN in the ventral midbrain, bypassing STN and RN.