Table 3.
Effects of the histamine H4 receptor antagonist JNJ7777120 on the vestibular deficit syndrome, home cage locomotor activity and exploratory behavior at 72 h post-vestibular lesion (VL).
| Vestibular deficit score (%) | Home cage locomotor activity (counts/min) | Exploratory behavior | ||||
|---|---|---|---|---|---|---|
| Total distance traveled (cm) | Center-point moving (s) | Highly mobile duration (s) | Immobile duration (s) | |||
| AVL EXPERIMENT | ||||||
| AVL-Veh | 86.81 ± 4.43*** | 23.77 ± 4.71*** | 361.57 ± 35.00*** | 138.26 ± 29.14* | 13.80 ± 2.64*** | 59.46 ± 35.86*** |
| AVL-JNJ | 63.19 ± 5.63***### | 13.25 ± 2.63### | 53.44 ± 36.57**### | 62.09 ± 36.30*### | 1.70 ± 1.01### | 160.45 ± 19.18***### |
| SHAM-Veh | 0.00 ± 0.00 | 10.67 ± 2.22 | 109.84 ± 10.48 | 104.54 ± 12.48 | 1.80 ± 1.50 | 125.28 ± 6.26 |
| SHAM-JNJ | 0.00 ± 0.00 | 9.75 ± 2.63 | 99.12 ± 12.37 | 93.85 ± 15.32 | 0.56 ± 0.35 | 131.25 ± 4.67 |
| IVL EXPERIMENT | ||||||
| IVL-Veh | 83.33 ± 5.55*** | 18.09 ± 2.06** | 85.19 ± 18.29* | 123.83 ± 22.45 | 3.86 ± 1.60* | 123.23 ± 21.83 |
| IVL-JNJ | 56.94 ± 7.71***### | 7.42 ± 1.53### | 50.01 ± 14.02***# | 68.52 ± 28.40**## | 1.13 ± 1.03# | 153.86 ± 20.10**# |
| SAL-Veh | 0.00 ± 0.00 | 10.52 ± 3.72 | 115.15 ± 25.02 | 103.75 ± 13.24 | 0.47 ± 0.28 | 117.68 ± 16.40 |
| SAL-JNJ | 0.00 ± 0.00 | 8.57 ± 1.99 | 97.43 ± 15.31 | 107.20 ± 11.26 | 0.44 ± 0.32 | 122.86 ± 12.25 |
AVL, Arsanilate-induced Vestibular Lesion; SHAM, Sham control; IVL, IDPN-Induced Vestibular Lesion; SAL, Saline control Veh, vehicle solution; JNJ, JNJ7777120.
*
P < 0.05,
**
P < 0.01, and
***
P < 0.001 compared with corresponding SHAM-Veh or SAL-Veh group.
#
P < 0.05,
##
P < 0.01, and
###
P < 0.001 compared with corresponding AVL-Veh or IVL-Veh group.