Table 2.
Overview of response rates and downstaging success rates with 90Y-RE in patients with ICC
| Authora | Year | N | RECIST (%) | WHO (%) | EASL (%) | Downstaging success rate | Median time to response/downstagingb | Resection | LTX | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CR | PR | CR | PR | CR | PR | % | Months (range) | %c | %c | |||
| Ibrahim [67] | 2008 | 24 | 0 | 27 | – | – | 9 | 77 | 8 | – | 4 | 4 |
| Mouli [53] | 2013 | 46 | – | – | 0 | 25 | 9 | 64 | 13 | 3.6 | 11 | 2 |
| Rayar [70] | 2015 | 10 | – | – | – | – | – | – | 80 | 7.6 (3.4–16.7) | – | 0 |
| Edeline [63] | 2015 | 24 | 0 | 25 | – | – | – | – | 46 | – | 46 | 0 |
aThe patientpopulations of Ibrahim and Mouli (partially) overlap, as well as the populations of Rayar and Edeline
bRayar et al.: median time from start chemotherapy to resection in a study on chemotherapy and 90Y-RE as first-line treatment for ICC
cPercentage of the total population