Table 4.
Induction of hypertrophy after 90Y-RE
| Author | Year | Patients | Follow up period | Volume measurement | Degree of hypertrophy contralateral lobea | Degree of atrophy treated lobea | Response assessment | Response treated lobe | Response non-treated lobe |
|---|---|---|---|---|---|---|---|---|---|
| Jakobs [68] | 2008 | 32 | 139 days | CT/MRI | 21 % | 9 % | – | – | |
| Gaba [65] | 2009 | 20 | 3 months | CT/MRI | 40 % | 52 % | EASL | CR 40 % PR 50 % SD 10 % |
NA |
| Ahmadzadehfar [37] | 2013 | 24 | 44–66 days | MRI | 47 % | 8 % | PERCIST and RECIST | CR 8 % PR 74 % SD 8 % PD 8 % |
50 % PD |
| Edeline [39] | 2013 | 34 | 3 months | CT | 29 % | 23 %b | mRECIST | CR 30 % PR 33 % SD 30 % PD 7 % |
NA |
| Vouche [58] | 2013 | 83 | 1 month 1–3 months 3–6 months >9 months |
CT/MRI | 7 % 24 % 35 % 45 % |
2 % 4 % 21 % 32 % |
– | 20 % new lesions | |
| Garlipp [41] | 2014 | 35 141b |
46 days 33 daysb |
MRI | 29 % 62 %b |
8 % 12 %b |
RECIST | CR 4 % PR 19 % SD 73 % PD 4 % |
8 % new lesions 56 % lesion growth |
| Teo [73] | 2014 | 17 | 5,7 months | CT | 34 % | 22 % | RECIST | CR 12 % PR 29 % SD 35 % PD 24 % |
NA |
| Theysohn [56] | 2014 | 45 | 1 month 3 months 6 months 9 months 12 months |
CT | 7 % 23 % 31 % 36 % 40 % |
5 % 23 % 34 % 41 % 45 % |
– | – |
NA not applicable
aDegree of hypertrophy: (volume non-treated lobe posttreatment−volume non-treated lobe at baseline)/volume non-treated lobe at baseline. Degree of atrophy is calculated likewise. Median volume changes are reported in the study of Gaba and Vouche. The others report mean volume changes
bMatched pair analysis of RE vs PVE; PVE data are marked