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Summary of clinical study using molecular targeted therapies as a RS in HCC
| Study Type | Agent | No of patients | RT dose | Grade 3 toxicity | Response rate | References |
|---|---|---|---|---|---|---|
| Retrospective | Sorafenib (800 mg daily) | 13 | 30–54 Gy/1.8–5 Gy per fraction | 17% | 61% | [39] |
| Phase II | Sorafenib (400 mg twice daily) | 40 | 40–60 Gy/2.0–2.5 Gy per fraction | 11% | 55% | [40] |
| Phase I | Sorafenib (200 mg daily) | 24 | SBRT (39–54 Gy in 6 fractions) | DLT at sorafenib 400 mg daily | NA | [41] |
