Table 2. Adverse Events during DTX.
Overall | DTX | DTX+ADT | p value | |
---|---|---|---|---|
CTCAE grade ≤2, n (%) | ||||
Thrombocytopenia | 1 (2.1) | 1 (4.8) | 0 (0.0) | 0.266 |
Anemia | 8 (17.0) | 3 (14.3) | 5 (19.2) | 0.657 |
Aspartate/alanine aminotransferase increased | 14 (29.8) | 5 (23.8) | 9 (34.6) | 0.426 |
Nausea & vomiting | 29 (61.7) | 15 (71.4) | 14 (53.8) | 0.223 |
Diarrhea | 9 (19.1) | 6 (28.6) | 3 (11.5) | 0.144 |
Constipation | 13 (27.7) | 8 (38.1) | 5 (19.2) | 0.155 |
Peripheral neuropathy | 7 (14.9) | 3 (14.3) | 4 (15.4) | 0.917 |
Dry mouth | 14 (29.8) | 8 (38.1) | 6 (23.1) | 0.268 |
Dry eye | 12 (25.5) | 7 (33.3) | 5 (19.2) | 0.275 |
Edema limbs | 6 (12.8) | 2 (9.5) | 4 (15.4) | 0.554 |
Myalgia | 11 (23.4) | 6 (28.6) | 5 (19.2) | 0.457 |
CTCAE grade ≥3, n (%) | ||||
Febrile neutropenia | 8 (17.0) | 4 (19.0) | 4 (15.4) | 0.742 |
Anemia | 1 (2.1) | 0 (0.0) | 1 (3.8) | 0.369 |
Nausea & vomiting | 2 (4.3) | 2 (9.5) | 0 (0.0) | 0.112 |
Peripheral neuropathy | 2 (4.3) | 0 (0.0) | 2 (7.7) | 0.199 |
Fatigue | 2 (4.3) | 1 (4.8) | 1 (3.8) | 0.878 |
CTCAE, common terminology criteria for adverse events; DTX, docetaxel-based chemotherapy; ADT, androgen deprivation therapy.