Table 1.

Olanzapine Equivalents Based on DDDs, the Minimum Effective Dose Method, the Classical Mean Dose Method, and an International Consensus

Drug	DDD	DDD	OLA	OLA	OLA	OLA	OLA
	Oral Drug	Paren-teral/ Depot Drug	1mg Equ Oral Form. DDD Method	1mg eEqu Parenteral/ Depot Form. DDD Method	1mg Equ Oral Form. Minimum Effective Dose Method9	1mg Equ Oral Form. Classical Mean Dose Method10	1mg Equ Oral Form. Gardner et al.11
Acepromazine	100	50	10	5	—	—	—
Acetophenazine	50	—	5	—	—	—	—
Amisulpride	400	—	40	—	—	38.33	34.48
Aripiprazole	15	15	1.5	1.5	1.33	1.41	1.49
Asenapine	20	—	2	—	1.33	0.89	—
Benperidol	1.5	—	0.15	—	—	—	0.25
Bromperidol	10	10/3.3	1	1/0.33	—	—	—
Butaperazine	10	—	1	—	—	—	—
Cariprazine	—	—	—	—	—	—	—
Chlorproethazine	—	—	—	—	—	—	—
Chlorpromazine	300	100	30	10	—	38.88	30.30
Chlorprothixene	300	50	30	5	—	—	25
Clopenthixol	100	100	10	10	—	—	3.03
Clotiapine	80	80	8	8	—	—	5.00
Clozapine	300	300	30	30	40	30.62	20.00
Cyamemazine	—	—	—	—	—	—	—
Dixyrazine	50	30	5	3	—	—	—
Droperidol	—	2.5	—	0.25	—	—	0.5
Fluanisone	—	—	—	—	—	—	—
Flupentixol	6	n.i./4	0.6	n.i./0.4	—	—	0.50
Fluphenazine	10	n.i./1	1	n.i./0.1	—	—	0.60
Fluspirilene	—	n.i./0.7	—	n.i./0.07	—	—	—
Haloperidol	8	8/3.3	0.8	0.8/0.33	0.53	0.74	0.5
Iloperidone	—	—	—	—	—	—	—
Levomepromazine	300	100	30	10	—	—	20.00
Levosulpiride	400	—	40	—	—	—	—
Loxapine	100	—	10	—	—	—	3.03
Lurasidone	60	—	6	—	5.33	—	—
Melperone	300	300	30	30	—	—	—
Mesoridazine	200	200	20	20	—	—	14.93
Molindone	50	—	5	—	—	—	5.00
Moperone	20	20	2	2	—	—	—
Mosapramine	—	—	—	—	—	—	—
Olanzapine	10	10/10.0	1	1/1.0	1	1	1.00
Oxypertine	120	—	12	—	1	—	1.20
Paliperidone	6	n.i./2.5	0.6	n.i./0.25	0.4	—	0.45
Penfluridol	6	—	0.6	—	—	—	—
Perazine	100	100	10	10	—	—	—
Periciazine	50	20	5	2	—	—	2.50
Perphenazine	30	10/7.0	3	1/0.7	—	—	1.49
Pimozide	4	—	0.4	—	—	—	0.40
Pipamperone	200	—	20	—	—	—	—
Pipotiazine	10	n.i./5	1	n.i./0.5	—	—	—
Prochlorperazine	100	50	10	5	—	—	4.35
Promazine	300	100	30	10	—	—	—
Prothipendyl	240	240	24	24	—	—	—
Quetiapine	400	—	40	—	20	32.27	37.04
Remoxipride	300	300	30	30	—	—	10.64
Risperidone	5	n.i./2.7	0.5	n.i./0.27	0.27	0.38	0.30
Sertindole	16	—	1.6	—	1.6	1.08	1.00
Sulpiride	800	800	80	80	—	—	40.00
Sultopride	1200	—	120	—	—	—	—
Thiopropazate	60	—	6	—	—	—	—
Thioproperazine	75	20	7.5	2	—	—	—
Thioridazine	300	—	30	—	—	—	25.00
Tiapride	400	400	40	40	—	—	—
Tiotixene	30	—	3	—	—	—	1.49
Trifluoperazine	20	8	2	0.8	—	—	1.00
Trifluperidol	2	—	0.2	—	—	—	0.10
Triflupromazine	100	100	10	10	—	—	5.00
Veralipride	—	—	—	—	—	—	—
Ziprasidone	80	40	8	4	5.33	7.92	8.00
Zotepine	200	—	20	—	—	13.24	14.93
Zuclopenthixol	30	30/15	3	3/1.5	—	—	2.50

Note: DDD, defined daily dose; equ, equivalent; form, formulation.

The first 2 columns present the DDDs for oral and parenteral/depot drugs according to the WHO (http://www.whocc.no/). The following 2 columns show the doses that are equivalent to 1mg oral olanzapine according to the DDD method, and the last 3 columns show doses equivalent to 1mg oral olanzapine according to the minimum effective dose method,⁹ the mean dose method,¹⁰ and an international consensus.¹¹