Table 1.
Drug | DDD | DDD | OLA | OLA | OLA | OLA | OLA |
---|---|---|---|---|---|---|---|
Oral Drug | Paren-teral/ Depot Drug | 1mg Equ Oral Form. DDD Method | 1mg eEqu Parenteral/ Depot Form. DDD Method | 1mg Equ Oral Form. Minimum Effective Dose Method9 | 1mg Equ Oral Form. Classical Mean Dose Method10 | 1mg Equ Oral Form. Gardner et al.11 | |
Acepromazine | 100 | 50 | 10 | 5 | — | — | — |
Acetophenazine | 50 | — | 5 | — | — | — | — |
Amisulpride | 400 | — | 40 | — | — | 38.33 | 34.48 |
Aripiprazole | 15 | 15 | 1.5 | 1.5 | 1.33 | 1.41 | 1.49 |
Asenapine | 20 | — | 2 | — | 1.33 | 0.89 | — |
Benperidol | 1.5 | — | 0.15 | — | — | — | 0.25 |
Bromperidol | 10 | 10/3.3 | 1 | 1/0.33 | — | — | — |
Butaperazine | 10 | — | 1 | — | — | — | — |
Cariprazine | — | — | — | — | — | — | — |
Chlorproethazine | — | — | — | — | — | — | — |
Chlorpromazine | 300 | 100 | 30 | 10 | — | 38.88 | 30.30 |
Chlorprothixene | 300 | 50 | 30 | 5 | — | — | 25 |
Clopenthixol | 100 | 100 | 10 | 10 | — | — | 3.03 |
Clotiapine | 80 | 80 | 8 | 8 | — | — | 5.00 |
Clozapine | 300 | 300 | 30 | 30 | 40 | 30.62 | 20.00 |
Cyamemazine | — | — | — | — | — | — | — |
Dixyrazine | 50 | 30 | 5 | 3 | — | — | — |
Droperidol | — | 2.5 | — | 0.25 | — | — | 0.5 |
Fluanisone | — | — | — | — | — | — | — |
Flupentixol | 6 | n.i./4 | 0.6 | n.i./0.4 | — | — | 0.50 |
Fluphenazine | 10 | n.i./1 | 1 | n.i./0.1 | — | — | 0.60 |
Fluspirilene | — | n.i./0.7 | — | n.i./0.07 | — | — | — |
Haloperidol | 8 | 8/3.3 | 0.8 | 0.8/0.33 | 0.53 | 0.74 | 0.5 |
Iloperidone | — | — | — | — | — | — | — |
Levomepromazine | 300 | 100 | 30 | 10 | — | — | 20.00 |
Levosulpiride | 400 | — | 40 | — | — | — | — |
Loxapine | 100 | — | 10 | — | — | — | 3.03 |
Lurasidone | 60 | — | 6 | — | 5.33 | — | — |
Melperone | 300 | 300 | 30 | 30 | — | — | — |
Mesoridazine | 200 | 200 | 20 | 20 | — | — | 14.93 |
Molindone | 50 | — | 5 | — | — | — | 5.00 |
Moperone | 20 | 20 | 2 | 2 | — | — | — |
Mosapramine | — | — | — | — | — | — | — |
Olanzapine | 10 | 10/10.0 | 1 | 1/1.0 | 1 | 1 | 1.00 |
Oxypertine | 120 | — | 12 | — | 1 | — | 1.20 |
Paliperidone | 6 | n.i./2.5 | 0.6 | n.i./0.25 | 0.4 | — | 0.45 |
Penfluridol | 6 | — | 0.6 | — | — | — | — |
Perazine | 100 | 100 | 10 | 10 | — | — | — |
Periciazine | 50 | 20 | 5 | 2 | — | — | 2.50 |
Perphenazine | 30 | 10/7.0 | 3 | 1/0.7 | — | — | 1.49 |
Pimozide | 4 | — | 0.4 | — | — | — | 0.40 |
Pipamperone | 200 | — | 20 | — | — | — | — |
Pipotiazine | 10 | n.i./5 | 1 | n.i./0.5 | — | — | — |
Prochlorperazine | 100 | 50 | 10 | 5 | — | — | 4.35 |
Promazine | 300 | 100 | 30 | 10 | — | — | — |
Prothipendyl | 240 | 240 | 24 | 24 | — | — | — |
Quetiapine | 400 | — | 40 | — | 20 | 32.27 | 37.04 |
Remoxipride | 300 | 300 | 30 | 30 | — | — | 10.64 |
Risperidone | 5 | n.i./2.7 | 0.5 | n.i./0.27 | 0.27 | 0.38 | 0.30 |
Sertindole | 16 | — | 1.6 | — | 1.6 | 1.08 | 1.00 |
Sulpiride | 800 | 800 | 80 | 80 | — | — | 40.00 |
Sultopride | 1200 | — | 120 | — | — | — | — |
Thiopropazate | 60 | — | 6 | — | — | — | — |
Thioproperazine | 75 | 20 | 7.5 | 2 | — | — | — |
Thioridazine | 300 | — | 30 | — | — | — | 25.00 |
Tiapride | 400 | 400 | 40 | 40 | — | — | — |
Tiotixene | 30 | — | 3 | — | — | — | 1.49 |
Trifluoperazine | 20 | 8 | 2 | 0.8 | — | — | 1.00 |
Trifluperidol | 2 | — | 0.2 | — | — | — | 0.10 |
Triflupromazine | 100 | 100 | 10 | 10 | — | — | 5.00 |
Veralipride | — | — | — | — | — | — | — |
Ziprasidone | 80 | 40 | 8 | 4 | 5.33 | 7.92 | 8.00 |
Zotepine | 200 | — | 20 | — | — | 13.24 | 14.93 |
Zuclopenthixol | 30 | 30/15 | 3 | 3/1.5 | — | — | 2.50 |
Note: DDD, defined daily dose; equ, equivalent; form, formulation.
The first 2 columns present the DDDs for oral and parenteral/depot drugs according to the WHO (http://www.whocc.no/). The following 2 columns show the doses that are equivalent to 1mg oral olanzapine according to the DDD method, and the last 3 columns show doses equivalent to 1mg oral olanzapine according to the minimum effective dose method,9 the mean dose method,10 and an international consensus.11