Table 5. Arachidonic acid cascade in postmortem schizophrenia brain.
| Author | Brain bank | n | Sex (m/f) | Age | Death from suicide | Brain region | Technique | Inflammatory markers | Results |
|---|---|---|---|---|---|---|---|---|---|
| Durrenberger et al.98 | BBPDGU | scz 10 ctr 10 | scz 5/5 ctr 5/5 | scz 66 ctr 61 | NA | Temporal lobe (BA22) | PCR | ALOX5AP | ↓. |
| Fillman et al.86 | NSWTRC | scz 37 ctr 37 | scz 24/13 ctr 30/7 | scz 51 ctr 51 | NA | DLPFC (BA46) | PCR | PTGS2 | ↔ |
| Fillman et al.139 | SMRIAC | scz 35 ctr 35 | scz 26/9 ctr 26/9 | scz 43 ctr 44 | scz 7 | Middle frontal gyrus | PCR | PTGS2 | ↔ |
| Maida et al.140 | SFNC | scz 15 ctr 15 | scz 9/6 ctr 9/6 | scz 45 ctr 48 | scz 4 | PFC (BA8)*, TC (BA21 and BA22)# OC (BA18)# | WB, IHC | COX-1#, COX-2 #, cPGE2* | ↓*↔# |
| Rao et al.73 | HBTRC | scz 10 ctr 10 | scz 6/4 ctr 7/3 | scz 59 ctr 49 | NA | FC (BA10) | PCR, WB | COX-1#, COX-2*, LOX5#, LOX12#, LOX15#, cPLA2*, sPLA2*, iPLA2#, cPGES#, mPGES# | ↑*↔# |
| Tang et al.141 | VBBN | scz 38 ctr 38 | NA | scz 43 ctr 44 | NA | DLPFC (BA46) | PCR | PTGS1, PTGS2, PTGER3, CYP4Z1 | ↔ |
| Yokota et al.142 | NA | scz 17 ctr 22 | scz 12/5 ctr 13/9 | scz 69 ctr 71 | scz 0 | HPC | IHC | COX-2 | ↔ |
Abbreviations: ALOX5AP, 5-lypoxygenase activating protein; BA, Brodmann Area; BBPDGU, Brain Bank for Psychiatric Diseases at the Gottingen University; ctr, control; COX, cyclooxygenase; cPGE, cytosolic prostaglandin E; FC, frontal cortex; CYP; cytochrome P450; HBTRC, Harvard Brain Tissue Resource Centre; IHC, immunohistochemistry; LOX, lipoxygenase; NA, not available; NSWTRC, New South Wales Tissue Resource Centre; OC, occipital cortex; PCR, polymerase chain reaction; PLA, phospholipase; PFC, prefrontal cortex; PGES, prostaglandin E synthase; PTGS, prostaglandin endoperoxide synthase; PTGER, prostaglandin E receptor 3; scz, schizophrenia; SFNC, Stanley Foundation Neuropathology Consortium; SMRIAC; Stanley Medical Research Institute Array Collection, TC, temporal cortex; VBBN, Victorian Brain Bank Network; WB, western blot.
*, # indicate which variables results are representing.