Table 6. Substance P in postmortem schizophrenia brain.
| Author | Brain bank | n | Sex (m/f) | age | Death from suicide | Brain region | Technique | Inflammatory markers | Results |
|---|---|---|---|---|---|---|---|---|---|
| Burnet and Harrison151 | SFNC | scz 13 ctr 14 | scz 8/5 ctr 9/5 | scz 44 ctr 47 | scz 3 | ACC | AR | [125I]BH–substance P binding (NK1 receptor) | ↔ |
| Carletti et al.143 | SFNC | scz 14 ctr 15 | scz 9/5 ctr 9/6 | scz 44 ctr 48 | scz 4 | AG*, TC# | In situ hybridization binding assay | Preprotachykinin A*, NK1 receptor# | ↓*↔# |
| Harrington et al.144 | NA | scz 4 ctr 5 | scz 0/4 ctr 4/1 | scz 71 ctr 69 | NA | CT, PU | In situ hybridization | Preprotachykinin A | ↔ |
| Iadarola145 | DCCO | scz 12 ctr 9 | scz 10/2 ctr 8/1 | scz 33 ctr 45 | scz 9 | SN | RIA | Substance P | ↔ |
| Kleinman et al.146 | DCCO | scz 40 ctr 18 | NA | scz 48 ctr 50 | NA | FC, CT, NAS, PU, GB, HPL | RIA | Substance P | ↔ (increased in other non schizophrenia psychotic disorders) |
| Rioux et al.150 | NA | scz 5 ctr 5 | NA | scz 70 ctr 70 | NA | NAS#, PU*, CT# | AR | [125I]BH–substance P binding (NK1 receptor) | ↔*↑# |
| Roberts et al.149 | NA | scz 14 ctr 12 | scz 8/6 ctr 7/5 | scz 62 ctr 82 | scz 2 | TC (BA21/22)*, FC (BA4)*, PC (BA7)*, CI (BA24)*, HPC#, AG*, TH*, BG* | RIA | Substance P | ↔*↑# |
| Tooney et al.152 | NSWTRC | scz 6 ctr 6 | scz 6/0 ctr 5/1 | scz 44 ctr 43 | scz 2 ctr 3 | PFC (BA9) | IHC | NK1 receptor | ↑ (except layer VI) |
| Toru et al.148 | NA | scz 14 ctr 10 | scz 9/5 ctr 7/3 | scz 58 ctr 67 | NA | BG*, SN*, TH*, HPC*, TC*, PFC*, PC*, OFC# | RIA | Substance P | ↔*↑# |
| Weidenhofer et al.153 | NSWTRC | scz 12 ctr 15 | scz 10/2 ctr 13/2 | scz 48 ctr 48 | scz 3 | AG | IHC, PCR | NK1 receptor | ↔ |
| Zech and Bogerts147 | NA | scz 6 ctr 5 | scz 1/5 ctr 3/2 | scz 31 ctr 45 | NA | BG | IHC | Substance P | ↔ |
Abbreviations: ACC, anterior cingulate cortex; AG, amygdala; AR, autoradiography; BA, Brodmann Area; BG, basal ganglia; CI; cingulate cortex; CT, caudate; ctr, control; DCCO, District of Colombia Coroner's Office; FC, frontal cortex; HPC, hippocampus; HPL, hypothalamus; IHC, immunohistochemistry; NA, not available; NAS, nucleus accumbens; NK1, neurokinin 1; NSWTRC, New south wales tissue resource centre; OFC, orbitofrontal cortex; PC, parietal cortex; PCR, polymerase chain reaction; PFC, prefrontal cortex; PU, putamen; RIA, radioimmunoassay; scz, schizophrenia; SN, substantia nigra: SFNC, Stanley Foundation Neuropathology Consortium; TC, temporal cortex; TH, thalamus.
*, # indicate which variables results are representing.