Appendix Table 1.
Sensitivity Analyses for Primary Outcome (WOMAC Pain Score*)
| Variable | Mean Change From Baseline (95% CI), mm
|
Between−Group Difference
|
||
|---|---|---|---|---|
| Tai Chi (n = 106) | Physical Therapy (n = 98) | Tai Chi vs. Physical Therapy (95% CI), mm | PValue† | |
| Main results from Table 2 for comparison | 0.22 | |||
|
| ||||
| Week 12 | −167.2 (−190.4 to −144.9) | −143.0 (−167.4 to −118.6) | −24.2 (−57.9 to 9.6) | |
|
| ||||
| Week 24 | −158.6 (−182.9 to −134.3) | −124.3 (−150.0 to −98.5) | −34.3 (−69.8 to 1.1) | |
|
| ||||
| Week 52 | −138.8 (−166.7 to −110.8) | −121.0 (−150.0 to −91.9) | −17.8 (−58.1 to 22.4) | |
|
| ||||
| Score assigned baseline value if no 12-wk data (last observation carried forward) | ||||
| Week 12 | −137.6 (−160.6 to −114.7) | −116.0 (−140.0 to −92.1) | −21.6 (−54.6 to 11.4) | 0.20 (t test) |
| Via multiple imputation | 0.24–0.80 | |||
|
| ||||
| Week 12 | −158.6 (−184.4 to −132.9) | −141.0 (−168.9 to −113.1) | −17.6 (−54.7 to 19.5) | |
|
| ||||
| Week 24 | −152.0 (−179.2 to −124.8) | −127.0 (−157.3 to −96.7) | −25.0 (−65.1 to 15.0) | |
|
| ||||
| Week 52 | −132.2 (−164.4 to −100.1) | −116.9 (−147.5 to −86.3) | −15.4 (−60.9 to 30.2) | |
|
| ||||
| Adjusted for baseline body mass index | 0.23 | |||
| Week 12 | −166.8 (−190.2 to −143.4) | −143.1 (−167.5 to −118.8) | −23.7 (−57.5 to 10.1) | |
|
| ||||
| Week 24 | −157.1 (−181.6 to −132.6) | −123.9 (−149.7 to −98.1) | −33.2 (−68.8 to 2.4) | |
|
| ||||
| Week 52 | −137.4 (−165.6 to −109.3) | −120.8 (−149.9 to −91.7) | −16.6 (−57.1 to 23.9) | |
| Adjusted for race | 0.18 | |||
|
| ||||
| Week 12 | −166.6 (−189.9 to −143.3) | −141.1 (−165.5 to −116.7) | −25.5 (−59.3 to 8.3) | |
|
| ||||
| Week 24 | −157.9 (−182.3 to −133.5) | −121.6 (−147.4 to −95.7) | −36.4 (−71.9 to −0.81) | |
|
| ||||
| Week 52 | −137.8 (−165.7 to −109.9) | −118.2 (−147.2 to −89.2) | −19.6 (−59.8 to 20.7) | |
|
| ||||
| Adjusted for analgesic use at the corresponding visit | 0.21 | |||
| Week 12 | −165.5 (−188.4 to −142.5) | −140.9 (−164.9 to −116.8) | −24.6 (−57.8 to 8.6) | |
|
| ||||
| Week 24 | −157.2 (−181.4 to −132.9) | −125.8 (−151.4 to −100.1) | −31.4 (−66.7 to 3.9) | |
|
| ||||
| Week 52 | −134.8 (−162.7 to −106.8) | −121.9 (−150.7 to −93.1) | −12.9 (−53.0 to 27.2) | |
| Adjusted for 6-min walk (in meters) at the corresponding visit | 0.52 | |||
|
| ||||
| Week 12 | −156.7 (−179.1 to −134.3) | −142.2 (−165.7 to −118.7) | −14.5 (−46.7 to 17.7) | |
|
| ||||
| Week 24 | −146.0 (−171.1 to −121.0) | −119.5 (−145.8 to −93.2) | −26.5 (−62.6 to 9.5) | |
|
| ||||
| Week 52 | −133.9 (−161.0 to −106.8) | −116.0 (−144.5 to −87.5) | −17.9 (−57.0 to 21.2) | |
|
| ||||
| Adjusted for SF-36 physical component summary at the corresponding visit | 0.84 | |||
| Week 12 | −142.3 (−163.4 to −121.2) | −134.1 (−155.8 to −112.4) | −8.2 (−38.0 to 21.7) | |
|
| ||||
| Week 24 | −130.0 (−152.8 to −107.2) | −115.9 (−139.6 to −92.2) | −14.1 (−46.5 to 18.3) | |
|
| ||||
| Week 52 | −116.5 (−141.5 to −91.5) | −103.2 (−129.0 to −77.4) | −13.3 (−48.7 to 22.1) | |
SF-36 = 36-Item Short Form Health Survey; WOMAC = Western Ontario and McMaster Universities Osteoarthritis Index.
*
Range, 0–500 mm. Sensitivity analyses were performed using the multiple imputation method (multivariate chained equation) to examine the effect of missing observations. All variables shown in Appendix Table 3 were included in the multiple imputation. There were 5 imputed data sets in total. Higher scores for all variables indicate more severe disease status.
†
Interaction P value unless otherwise indicated.