Table 3.
Number of Disease Risk Loci with Possible Underlying Expression Mechanisms in Seven Common Diseases
Disease set | BD | CAD | CD | HT | RA | T1D | T2D |
---|---|---|---|---|---|---|---|
All loci included | 65 | 45 | 84 | 17 | 34 | 50 | 42 |
0 cM | 13 | 8 | 24 | 3 | 12 | 12 | 7 |
0.005 cM | 20 | 15 | 37 | 6 | 18 | 19 | 10 |
0.05 cM | 26 | 23 | 48 | 8 | 21 | 24 | 13 |
Data at three thresholds of agreement between disease and expression markers are included where at least one disease and expression SNP are identical (0 cM), where a disease and expression marker are <0.005 cM apart, and where the markers are <0.05 cM apart.
BD, bipolar disorder; CAD, coronary artery disease; CD, Crohn's disease; HT, hypertension; RA, rheumatoid arthritis; SNP, single-nucleotide polymorphism; T1D, type 1 diabetes; T2D, type 2 diabetes.