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. 2016 Jul 26;6:30155. doi: 10.1038/srep30155

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Each colored line represents the response of a different single cell (a) Control using endogenous CXCR4 agonist SDF-1 (100 nM) shows two strong (Ca)i responses. Addition of ATP (10 μM) to activate purinergic receptors was performed as a positive control for cell viability (b) Antagonist NUCC-388 (10 μM) blocks the effect of SDF-1. (c) Agonist NUCC-390 (10 μM) produces strong (Ca)i response which is blocked by the known potent and selective CXCR4 antagonist AMD3100 (1 μM). (d) Agonist effects of NUCC-398 (10 μM). (e) Comparison of the effects of SDF-1 and NUCC-390 averaged over 74 cells.