Fig. 1.

Effect of azithromycin on spleen weight in mice subjected to transient MCAo. Quantification of spleen size expressed as absolute weight (A) or as ratio of spleen to body weight (B). Mice subjected to 30-min MCAo, followed by 48 h of reperfusion, show a significant reduction in their spleen size as compared with sham-operated animals. Conversely, in mice treated with azithromycin (150 mg/kg, i.p., upon reperfusion), spleen weight was unaffected by the ischemic insult. *P < 0.05 versus sham (one-way ANOVA followed by Tukey's multiple-comparison test, n = 5 animals per experimental group). ANOVA, analysis of variance; i.p., intraperitoneal; MCAo, middle cerebral artery occlusion.