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. 2016 Jul 26;6:24530. doi: 10.1038/srep24530

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Infection of DCs by DENV induced expression and production of IFN-λ1, and this effect was dependent on TLR-3, NF-κB and IRF-3 signaling. Viral NS1 was the main viral component responsible for the observed effects on activating NF-κB and IRF-3 signaling. Through IFN-λR1 and IL-10-RB, IFN-λ1 activated the NF-κB and AP-1 signaling pathways, regulated CCR7 expression and facilitated cell migration from periphery to lymphoid organs like spleen.