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. 2016 Jul 26;6:30464. doi: 10.1038/srep30464

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Copyright © 2016, The Author(s)

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Active PAI-1 in rat cerebrospinal fluid (CSF) (a) and serum (b) of rats. (a) The active PAI-1 concentration (ng/ml) in CSF was increased by stress in the CS group, whereas escitalopram did not change the level in the CE group compared with the CS group. (b) There was a trend for increased active PAI-1 (ng/ml) in the serum of the CS group compared with the NS group, which decreased with escitalopram treatment. However, escitalopram treatment increased active PAI-1 expression in the NE group. The data are expressed as the means ± standard error of mean (n = 6/group). *P < 0.05 and **P < 0.01. CSF: cerebrospinal fluid. Nor: normal; Esc: escitalopram. CS: CUMS + saline; CE: CUMS + escitalopram; NS: normal + saline; NE: normal + escitalopram.