Table 2. PAI-1 levels in several brain subregions, cerebrospinal fluid and serum of rats among different groups (M ± SEM).

	Normal + saline	Normal + Esc	CUMS + saline	CUMS + Esc
Cg1	0.22 ± 0.01	0.10 ± 0.00	0.88 ± 0.02**	0.67 ± 0.02##
PrL	0.32 ± 0.02	0.35 ± 0.02	0.81 ± 0.04**	0.55 ± 0.03##
CA1	0.43 ± 0.02	0.57 ± 0.02	0.25 ± 0.01**	0.27 ± 0.01
CA3	0.26 ± 0.01	0.12 ± 0.00	1.00 ± 0.04**	0.47 ± 0.02##
DG	0.60 ± 0.02	0.40 ± 0.01	0.93 ± 0.04**	0.69 ± 0.02##
CSF (ng/ml)	1.38 ± 0.22	2.95 ± 0.51	3.55 ± 0.32**	3.44 ± 0.18
Serum (ng/ml)	1.16 ± 0.17	4.66 ± 0.48	2.50 ± 0.50	0.74 ± 0.10#

Note: The protein levels of PAI-1 in Cg1, PrL, CA1, CA3 and DG were normalized to GAPDH. M: mean; SEM: standard error of mean; Esc: escitalopram; CUMS: chronic unpredictable mild stress; Cg1: area 1 of the cingulate cortex; PrL: prelimbic cortex; CA1: cornu ammonis 1; CA3: cornu ammonis 3; DG: dentate gyrus. CSF: cerebrospinal fluid.

Compared with “Normal + saline” group by post-hoc analysis, *P <0.05, **P < 0.01. Compared with “CUMS + saline” group by post-hoc analysis, ^#P < 0.05, ^##P < 0.01.