Table 1. Protective effect of BSE and SFN on diabetes-induced cardiac dysfunction.
WT | WT-BSE-low | WT-BSE-high | WT-SFN | db/db | db/db -BSE-low | db/db -BSE-high | db/db -SFN | |
---|---|---|---|---|---|---|---|---|
IVS; d (mm) | 0.63 ± 0.00 | 0.62 ± 0.02 | 0.62 ± 0.02 | 0.63 ± 0.03 | 0.63 ± 0.03 | 0.62 ± 0.02 | 0.61 ± 0.02 | 0.63 ± 0.04 |
LVID; d (mm) | 3.74 ± 0.02 | 3.74 ± 0.06 | 3.76 ± 0.01 | 3.79 ± 0.02 | 4.09 ± 0.08* | 4.12 ± 0.07* | 4.05 ± 0.06* | 4.06 ± 0.05* |
LVPW; d (mm) | 0.85 ± 0.05 | 0.82 ± 0.05 | 0.80 ± 0.04 | 0.85 ± 0.06 | 0.84 ± 0.03 | 0.82 ± 0.04 | 0.78 ± 0.03 | 0.79 ± 0.04 |
IVS; s (mm) | 1.01 ± 0.03 | 0.99 ± 0.02 | 0.96 ± 0.07 | 1.00 ± 0.02 | 1.00 ± 0.02 | 1.00 ± 0.02 | 0.98 ± 0.02 | 0.99 ± 0.03 |
LVID; s (mm) | 2.06 ± 0.05 | 2.04 ± 0.03 | 2.07 ± 0.06 | 2.09 ± 0.03 | 2.83 ± 0.08* | 2.65 ± 0.07*,# | 2.50 ± 0.05*,# | 2.48 ± 0.04*,# |
LVPW; s (mm) | 1.29 ± 0.02 | 1.30 ± 0.01 | 1.28 ± 0.02 | 1.28 ± 0.03 | 1.30 ± 0.02 | 1.28 ± 0.02 | 1.27 ± 0.02 | 1.30 ± 0.04 |
LV Vol; d (mm) | 59.52 ± 0.60 | 59.54 ± 2.18 | 60.22 ± 0.61 | 61.62 ± 0.61 | 73.93 ± 2.59* | 74.89 ± 2.45* | 71.98 ± 2.40* | 72.56 ± 2.17* |
LV Vol; s (mm) | 13.72 ± 0.71 | 13.42 ± 0.53 | 13.88 ± 0.98 | 14.19 ± 0.54 | 31.43 ± 0.74* | 25.72 ± 1.81*,# | 22.37 ± 1.00*,# | 21.97 ± 0.89*,# |
%EF | 76.94 ± 1.16 | 77.44 ± 1.35 | 76.94 ± 1.70 | 76.98 ± 0.65 | 57.93 ± 1.32* | 65.67 ± 2.21*,# | 68.88 ± 1.94*,# | 69.72 ± 0.78*,# |
%FS | 44.88 ± 1.10 | 45.36 ± 1.33 | 44.90 ± 1.60 | 44.95 ± 0.61 | 30.18 ± 0.92* | 35.72 ± 1.66*,# | 38.16 ± 1.59*,# | 38.84 ± 0.64*,# |
LV Mass (mg) | 94.31 ± 4.69 | 88.55 ± 1.29 | 90.37 ± 4.10 | 92.42 ± 6.81 | 109.27 ± 4.86* | 106.74 ± 5.08* | 101.33 ± 0.96*,# | 101.10 ± 3.95*,# |
Notes: IVS: interventricular septum; LVID; d: left ventricular internal diastolic diameter; LVID; s: left ventricular internal systolic diameter; LVPW: left ventricular posterior wall; EF: ejection fraction; FS: fractional shortening; LV vol; s: left ventricular end systolic volume; LV vol; d: left ventricular end diastolic volume; LV mass: left ventricular mass. Data are presented as means ± SD. *p < 0.05 vs. WT group; #p < 0.05 vs. db/db group.