Table 2. Genotype frequencies of the TSHR SNPs in the studies included in the meta-analysis.

SNP	Study	Ethnicity	Case			Control			Genotyping method
			1*	2*	3*	1*	2*	3*
GD rs179247A/G	Brand (2009)	Caucasian	279	359	100	182	322	100	TaqMan
	Ploski (2010)	Caucasian	139	270	149	81	259	180	TaqMan
		Caucasian	58	84	54	34	98	67
		Caucasian	879	1110	351	737	1243	561
	Liu (2012)	Chinese	230	140	24	120	88	20	MALDI-TOF-MS
	Inoue (2013)	Japanese	57	44	11	18	33	5	PCRRFLP
	Bufalo (2015)	Brazilian	117	138	24	92	154	50	TaqMan
GD rs12101255C/T	Brand (2009)	Caucasian	197	345	150	268	295	89	TaqMan
	Ploski (2010)	Caucasian	238	245	75	273	212	35	TaqMan
		Caucasian	70	94	32	110	71	17
		Caucasian	687	1136	482	1046	1148	338
	Liu (2012)	Chinese	38	179	187	35	119	86	MALDI-TOF-MS
GO rs2268458 T/C	Yin (2008)	Caucasian	67	43	10	38	32	10	PCR-RFLP
	Yin (2012)	Caucasian	139	99	18	44	36	10	PCR-RFLP
GO rs179247A/G	Liu (2012)	Chinese	62	33	3	168	107	21	MALDI-TOF-MS
	Jurecka (2014)	Caucasian	80	126	77	91	148	77	PCR-RFLP
	Bufalo (2015)	Brazilian	54	78	12	63	60	12	TaqMan

(1*, Homozygous wild type; 2*, Heterozygous variant; 3*, Homozygous variant).