Figure 7. Differential sensitivity of OFF BC types to AMPA- and kainate receptor blockers.

GYKI 52466 partly blocked the sustained component of the glutamate response in BC-2, 3b and 4 without affecting the maximum response amplitude (A,E,G), but had no significant effect on BC-3a (C). SYM 2081, a desensitizing agonist of kainate-type receptors, partly blocked the responses of all OFF BC types tested (B,D,F,H). Note the baseline shift and the transient response caused by SYM prior to the glutamate stimulus in BC-2 and 3b (B,F). Complete recovery from receptor blockage was observed in all experiments (green traces). Data for BC-1 and 2′ were not included (n = 1) and data for BC-4 have in part been published previously¹³.