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. 2016 Jul 26;6:30451. doi: 10.1038/srep30451

Figure 1. Airway resistance (Penh) of Balb/c mice versus methacholine (MCh) concentration.

Figure 1

Penh was measured by using whole-body plethysmography when mice were stimulated with MCh at increasing doses. In all cases, Penh increased with increasing MCh. However, Penh of mice (OVA, open circles), as compared to non-sensitized mice (Control, solid circles) increased to a much greater extent in response to increasing dose of MCh stimulation, indicating bronchial hyperresponsivess (BHR). This large response of Penh to MCh in OVA-sensitized and challenged mice was attenuated dose dependently by treatment with BK-1361 (OVA, open circles versus 10 μg, solid triangles, and 25 μg, open triangles, respectively). There are statistical significances between OVA and Control, OVA and 25 μg, Control and 10 μg, Control and 25 μg, 10 μg and 25 μg (P < 0.05). Data are representative of two independent experiments with n = 8–10 age-matched female mice for each group. Results are expressed as mean ± SEM. *P < 0.05 versus control. #P < 0.05 versus OVA.