Table 2. Genotypes of MTRR, MTHFR, MTR and TS polymorphism with gastric cancer patients’ survival in both cohorts.
| Genetic model | Genotypes | Chemotherapy | No chemotherapy | ||||
|---|---|---|---|---|---|---|---|
| MST (mouths) | P | HR (95% CI)a | MST (mouths) | p | HR (95% CI)a | ||
| MTRR rs1801394 66 A > G | |||||||
| Codominant model | AA | 46 | 0.089 | 1 | 38 | 0.419 | 1 |
| GA | 72b | 0.675 (0.452–1.007) | 62 | 0.880 (0.659–1.176) | |||
| GG | 85b | 0.526 (0.192–1.443) | 62 | 0.683 (0.347–1.344) | |||
| Dominant model | GA/GG | 80b | 0.031 | 0.657 (0.446–0.967) | 62 | 0.853 (0.645–1.129) | |
| TYMS 5-UTR 2R > 3R | |||||||
| Codominant model | 2R2R | 23 | 0.024 | 1 | 60b | 0.600 | 1 |
| 2R3R | 51 | 0.629 (0.312–1.268) | 50 | 1.433 (0.658–3.124) | |||
| 3R3R | 70b | 0.435 (0.221–0.857) | 50 | 1.474 (0.687–3.164) | |||
| Dominant model | 2R3R/3R3R | 73b | 0.032 | 0.498 (0.259–0.960) | 50 | 0.320 | 1.459 (0.685–3.106) |
| Recessive model | 2R2R/2R3R | 39 | 0.022 | 1 | 56 | 0.643 | 1 |
| 3R3R | 70b | 0.637 (0.430–0.944) | 50 | 1.071 (0.800–1.433) | |||
| MTHFR rs1801131 1298 A > C | |||||||
| Codominant model | AA | 62 | 0.55 | 1 | 48 | 0.739 | 1 |
| CA | 72b | 1.011 (0.656–1.559) | 48 | 1.012 (0.747–1.371) | |||
| CC | 69b | 0.471(0.116–1.918) | 68b | 0.585 (0.145–2.362) | |||
| Dominant model | CA/CC | 75b | 0.771 | 0.940 (0.616–1.433) | 48 | 0.934 | 0.987 (0.732–1.333) |
| MTHFR rs1801133 677C > T | |||||||
| Codominant model | CC | 72b | 0.697 | 1 | 38 | 0.610 | 1 |
| TC | 59b | 1.169 (0.771–1.774) | 43 | 0.973 (0.694–1.266) | |||
| TT | 55 | 0.983 (0.555–1.741) | 63 | 0.814 (0.541–1.226) | |||
| Dominant model | TC/TT | 60b | 0.587 | 1.118 (0.753–1.659) | 48 | 0.904 (0.679–1.203) | |
| MTR rs1805087 2756 A > G | |||||||
| Codominant model | AA | 62 | 0.613 | 1 | 53 | 0.059 | 1 |
| GA | 73 | 0.943 (0.559–1.591) | 42 | 1.3699 (0.957–1.958) | |||
| GG | 0 | 0 | 0 | ||||
| Dominant model | GA/GG | 64b | 0.681 | 0.897 (0.532–1.513) | 26 | 0.205 | 1.257 (0.879–1.797) |
| TYMS 3-UTR 6bp ins > del | |||||||
| Codominant model | I/I | 46 | 0.171 | 1 | 55b | 0.811 | 1 |
| D/I | 50 | 1.028 (0.539–1.961) | 47 | 1.207 (0.677–2.151) | |||
| D/D | 71b | 0.703 (0.359–1.376) | 50 | 1.192 (0.668–2.128) | |||
| Dominant model | DI/DD | 72b | 0.654 | 0.868 (0.456–1.620) | 48 | 0.521 | 1.200 (0.684–2.104) |
aAdjusted for age and sex.
bMean survival time was provided when MST could not be calculated.
2R, 2-repeat; 3R, 3-repeat; I, 6-bp insertion; D; 6-bp deletion; P, Log-rank p.