. 2016 Jul 26;6:28019. doi: 10.1038/srep28019

Table 3. Stratified analysis of the MTRR 66A > G polymorphism with gastric cancer overall survival in patients received adjuvant chemotherapy.

Variables	Genotypes (Dominant model)		MST (AA/GA + GG)	HR (95% CI)^a	P _{Heterogeneity}
	AA	GA/GG
Total	136/69	113/41	46/80^b	0.657 (0.446–0.967)	0.031
Age
≤60	73/35	69/25	52/73^b	0.697 (0.416–1.165)	0.163
>60	63/34	44/16	42/79^b	0.622 (0.343–1.127)	0.109
Tumor size
≤5 cm	77/38	64/21	46/84^b	0.607 (0.356–1.036)	0.062
>5 cm	59/31	49/20	51/67^b	0.725 (0.413–1.273)	0.255
Tumor site
Non-cardia	88/44	68/25	43/72^b	0.645 (0.394–1.054)	0.076
Cardia	48/25	45/16	51/80^b	0.700 (0.373–1.311)	0.259
Histological type
Intestinal type	40/20	32/15	51/58^b	0.891 (0.456–1.743)	0.734
Diffuse type	96/49	81/26	43/83^b	0.573 (0.356–0.923)	0.019
Tumor differentiation
Well to moderately	37/19	30/14	46/57^b	0.864 (0.433–1.724)	0.676
poor	80/40	71/19	50/89^b	0.460 (0.266–0.795)	0.004
mucinous /signet-ring cell	19/10	12/8	43/20	1.514 (0.592–3.871)	0.382
Depth of invasion
T1/T2	8/5	16/8	24/56^b	0.681 (0.222–2.088)	0.495
T3/T4	128/64	97/33	50/82^b	0.631 (0.414–0.961)	0.029
Lymph node metastasis
N0	29/10	22/8	70b/65^b	1.276 (0.502–3.244)	0.606
N1/N2/N3	107/59	91/33	39/80^b	0.562 (0.367–0.863)	0.007
Distant metastasis
M0	136/69	113/41	46/80^b	0.657 (0.446–0.967)	0.031
TNM stage
II	36/15	35/14	62/63^b	1.073 (0.517–2.226)	0.849
III	100/54	78/27	39/81^b	0.557 (0.350–0.885)	0.011

^aAdjusted for age and sex.

^bHeterogeneity test for differences between groups.

^cInformation was not available for two patients.