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Loss of epidermal HS disrupts the distribution of morphogens. The knockout of Ext1 in keratin 14 expressing cells (Ext1 Δ/ΔEpi) leads to a loss of epidermal HS disrupting β‐catenin and SHH distribution at the epidermal–mesenchymal junction in comparison with wild‐type mice (wt). The epidermis (Epi), a sebaceous gland (SB), a hair follicle (HF) and the underlying dermis (*) are shown in the figure.
