. 2016 Jul 6;97(3):278–284. doi: 10.1111/iep.12190

Table 2.

Effect of phenylbutyrate on amino acids, ammonia and urea in blood plasma following PH

	Hours	Sham + Sal	Sham + NaPB	PH + Sal	PH + NaPB
Glutamine	18 h	634 ± 6	530 ± 16	663 ± 28	1526 ± 145* ^, #
	24 h	616 ± 9	476 ± 14	600 ± 17	735 ± 95#
	48 h	620 ± 13	518 ± 28*	687 ± 33	671 ± 24#
Glutamate	18 h	100 ± 4	76 ± 10	68 ± 5	130 ± 15* ^, #
	24 h	86 ± 3	76 ± 8	65 ± 3	68 ± 9
	48 h	106 ± 4	176 ± 20 *	72 ± 4	140 ± 5 *
Alanine	18 h	368 ± 13	305 ± 16	319 ± 18	997 ± 161* ^, #
	24 h	247 ± 15	285 ± 21	315 ± 19	504 ± 63* ^, #
	48 h	375 ± 13	494 ± 52 *	419 ± 20	408 ± 22
Phenylalanine	18 h	63 ± 1	57 ± 2	88 ± 4	151 ± 29* ^, #
	24 h	67 ± 3	56 ± 2	76 ± 3	100 ± 20#
	48 h	62 ± 2	67 ± 4	66 ± 4	81 ± 3* ^, #
Tyrosine	18 h	93 ± 3	77 ± 5	108 ± 7	236 ± 27* ^, #
	24 h	79 ± 3	81 ± 4	104 ± 6	210 ± 67#
	48 h	84 ± 4	67 ± 6	106 ± 7#	103 ± 4#
Valine	18 h	171 ± 4	104 ± 7 *	167 ± 10	220 ± 23* ^, #
	24 h	179 ± 12	113 ± 6 *	153 ± 6	109 ± 16 *
	48 h	167 ± 8	141 ± 9	139 ± 7	103 ± 10* ^, #
Isoleucine	18 h	93 ± 3	44 ± 3 *	89 ± 5	71 ± 8#
	24 h	105 ± 6	47 ± 3 *	79 ± 3#	36 ± 6 *
	48 h	87 ± 4	65 ± 5 *	67 ± 4#	35 ± 2* ^, #
Leucine	18 h	150 ± 4	84 ± 6 *	147 ± 9	148 ± 16#
	24 h	159 ± 10	90 ± 5 *	129 ± 6#	74 ± 11 *
	48 h	142 ± 6	113 ± 8*	112 ± 6#	62 ± 3* ^, #
BCAA	18 h	414 ± 10	232 ± 16 *	402 ± 23	438 ± 47#
	24 h	443 ± 28	250 ± 14 *	361 ± 14	191 ± 22 *
	48 h	397 ± 17	319 ± 21	318 ± 16#	201 ± 14* ^, #
∑ of all amino acids	18 h	3629 ± 64	3216 ± 123	3539 ± 135	7603 ± 815* ^, #
	24 h	3387 ± 92	2919 ± 93	3310 ± 99	4385 ± 762#
	48 h	3476 ± 65	3419 ± 217	3811 ± 175	3715 ± 91
Ammonia	18 h	27.5 ± 6.3	51.7 ± 11.9	33.5 ± 6.3	99.4 ± 15.7* ^, #
	24 h	33.2 ± 9.5	39.2 ± 7.9	22.8 ± 4.0	52.4 ± 9.6
	48 h	39.7 ± 8.0	39.1 ± 5.6	52.1 ± 10.1	48.9 ± 6.6
Urea	18 h	6.56 ± 0.35	7.13 ± 0.43	3.81 ± 0.28#	8.85 ± 0.59* ^, #
	24 h	6.70 ± 0.39	6.03 ± 0.35	3.40 ± 0.31#	5.92 ± 0.43*
	48 h	5.19 ± 0.55	4.78 ± 0.49	4.66 ± 0.31	4.44 ± 0.35

Means ± SE, anova and Bonferroni multiple comparisons. *P ˂ 0.05, effect of NaPB (compared to the corresponding saline‐treated group); # P ˂ 0.05, effect of PH (compared to the corresponding sham‐operated group). Amino acid and ammonia concentrations are expressed in μmol/L; concentrations of urea in mmol/L. BCAA, branched‐chain amino acids; NaPB, sodium phenylbutyrate; PH, partial hepatectomy; Sal, saline.