Table 3.
Galectin-3 Is Associated with Measures of Pulmonary Structure and Function
| PFT Measures | Age, Sex, and Height Adjusted |
Multivariable Adjusted* |
||
|---|---|---|---|---|
| β Value (SE) | P Value | β Value (SE) | P Value | |
| FEV1, % predicted | −1.4 (0.3) | <0.001 | −1.0 (0.3) | 0.001 |
| FVC, % predicted | −1.2 (0.3) | <0.001 | −0.7 (0.3) | 0.008 |
| FEV1/FVC, % predicted | −0.2 (0.2) | 0.21 | −0.3 (0.2) | 0.07 |
| TLC, % predicted | −1.0 (0.5) | 0.04 | −0.7 (0.5) | 0.16 |
| DlCO, % predicted | −2.1 (0.4) | <0.001 | −2.2 (0.4) | <0.001 |
| Chest CT Measures | OR (95% CI) | P Value | OR (95% CI) | P Value |
|---|---|---|---|---|
| ILA | 1.57 (1.27–1.94) | <0.001 | 1.59 (1.28–1.97) | <0.001 |
| Fibrosis | 1.68 (1.14–2.45) | 0.008 | 1.65 (1.11–2.44) | 0.01 |
Definition of abbreviations: CI = confidence interval; CT = computed tomography; DlCO = diffusing capacity of the lung for carbon monoxide; ILA = interstitial lung abnormality; OR = odds ratio; PFT = pulmonary function test; TLC = total lung capacity.
β-Coefficient and odds ratio are change in pulmonary trait per 1 SD of log-transformed galectin-3.
*
Adjusted for age, sex, height, body mass index, current or former smoking status, pack-years of smoking, and diabetes.