Table 3.
Top 10 Results from Meta-analysis Across All Cohorts of SKAT-O Gene-based Association with Moderate to Severe COPD
| Gene Set | BEOCOPD and ICGN | TCGS-Korea | TCGS-Poland | COPDGene AA | COPDGene NHW | Meta-analysis |
|---|---|---|---|---|---|---|
| KIAA0020 | 0.054 | 0.34 | 0.51 | 0.47 | 1.3 × 10−3 | 1.2 × 10−4 |
| AGER | 0.34 | 0.35 | 0.48 | 0.42 | 1.7 × 10−5 | 1.3 × 10−4 |
| RRP1B | 0.33 | 0.69 | 0.49 | 4.9 × 10−5 | 0.25 | 1.6 × 10−4 |
| SQSTM1 | 0.045 | — | 0.74 | 0.35 | 2.2 × 10−3 | 1.6 × 10−4 |
| RUFY4 | 0.060 | 0.11 | 0.63 | 0.14 | 0.040 | 2.3 × 10−4 |
| TYRO3 | 0.36 | — | — | 7.8 × 10−5 | 0.18 | 2.8 × 10−4 |
| IKZF2 | 0.078 | — | 0.58 | 0.12 | 0.011 | 4.2 × 10−4 |
| TAF12 | 6.6 × 10−3 | — | 0.43 | — | 0.025 | 4.4 × 10−4 |
| GON4L | 1 | 0.86 | 0.40 | 4.9 × 10−4 | 0.24 | 7.3 × 10−4 |
| MYEOV2 | 0.023 | — | 0.39 | 9.1 × 10−3 | 0.13 | 9.1 × 10−4 |
Definition of abbreviations: AA = African Americans; BEOCOPD = Boston Early-Onset COPD; COPD = chronic obstructive pulmonary disease; COPDGene = Genetic Epidemiology of COPD; ICGN = International COPD Genetics Network; NHW = non-Hispanic whites; SKAT-O = SNP-set (Sequence) Kernel Association Test; TCGS = Transcontinental COPD Genetics Study.
Results are given as P values. Gene sets present in at least three of the five cohort-level analyses are reported.