Figure 4. Tgfa knockout mice still show resistance to developing OA at 14 weeks post-surgery.

10 week-old Tgfa knockout mice and their heterozygous littermates received DMM surgery or sham surgery. At fourteen weeks post surgery, mice were sacrificed and their knee joints were prepared for histology. Tissues were stained with safranin-O and fast green (A) and then scored using the OARSI system for OA histopathology (B). DMM knockout animals still displayed lower OARSI scores than their heterozygous control littermates at this time point (DMM groups n = 6, sham groups n = 4, *p < 0.05). Independent data points for OARSI scores with mean ± SD are shown.