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. 2016 Jul 26;6:30433. doi: 10.1038/srep30433

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Experimental setup. (b) LFP recordings from the same mouse during ketamine/xylazine (KX) anaesthesia and wakefulness. (c) Frequency-domain spectra showing change in power distribution between KX anaesthesia and awake LFP from (b). (d) Upper, LFP recording showing development of seizure-like activity in primary sensori-motor cortex following 100 μM SR101 loading (10 min incubation). Note that movement artefacts have not been removed from the LFP. Lower, frequency power spectrograms from period 1 and 2 from LFP above. (e) Histograms showing individual seizure-like activity event amplitudes and intervals.