Table 1.
Comparisons of baseline features of patients with rapid virological response (RVR) and those with non-RVR
| Variables | RVR (N = 45) | Non-RVR (N = 34) | P value |
|---|---|---|---|
| Sex (M:F) | 23:22 | 19:15 | 0.674 |
| Age (median,IQR) | 60.5 (52.9 ~ 67.8) | 53.4 (43.9 ~ 63.0) | 0.003 |
| BMI, Kg/m2 (median,IQR) | 23.5 (21.8 ~ 24.7) | 26.4 (23.0 ~ 29.4) | 0.001 |
| ALT, IU/L(median,IQR) | 71.0 (48.0 ~ 138.5) | 84.5 (56.3 ~ 115.5) | 0.801 |
| HCV viral load (≥ vs < 4x105 IU/ml) | 17:28 | 28:6 | < 0.001 |
| Liver cirrhosis (yes vs. no) | 4:41 | 6:28 | 0.313 |
| > 80 % adherence (yes vs. no) | 32:13 | 24:10 | 0.960 |
| rs12979860 (CC vs. CT + TT) | 43:2 | 24:10 | 0.002 |
| rs 8099917 (TT vs. GG + GT) | 44:1 | 25:9 | 0.002 |
| TLR2 mRNA (median,IQR) | −1.36 (−2.52 ~ 0.76) | 0.82 (0.55 ~ 0.96) | 0.001 |
| TLR3 mRNA (median,IQR) | −2.66 (−3.13 ~ −1.28) | −1.47 (−1.90 ~ −1.27) | 0.014 |
| TLR4 mRNA (median,IQR) | −1.85 (−2.53 ~ 0.57) | 0.66 (0.31 ~ 0.86) | < 0.001 |
| TLR7 mRNA (median,IQR) | −2.41 (−3.19 ~ −0.07) | −0.77 (−1.18 ~ −0.57) | 0.008 |
| TLR9 mRNA (median,IQR) | −2.44 (−3.17 ~ −1.01) | −0.98 (−1.26 ~ −0.84) | 0.001 |
BMI body mass index, ALT alanine aminotransferase, TLR toll like receptor, TLR mRNA expressions were shown as log ratios relative to GAPDH mRNA (log 2 -(∆Ct)). > 80 % adherence: patients who received more than 80 % of standard dose and duration