Table 2.
Comparisons of baseline features of patients with sustained virological response (SVR) and those with non-SVR
| Variables | SVR (N = 45) | Non-SVR (N = 30) | P value |
|---|---|---|---|
| Sex (M:F) | 19:26 | 20:10 | 0.038 |
| Age (median,IQR) | 59.7 (51.1 ~ 67.4) | 56.6 (45.9 ~ 64.7) | 0.176 |
| BMI, Kg/m2 (median,IQR) | 23.9 (22.4 ~ 27.1) | 23.7 (21.4 ~ 27.8) | 0.787 |
| ALT, IU/L(median,IQR) | 84.0 (52.0 ~ 134.5) | 77.0 (44.8 ~ 14.8) | 0.423 |
| Viral load (≥ vs < 4 × 105 IU/ml) | 25:20 | 19:11 | 0.503 |
| RVR (yes vs. no) | 31:14 | 10:20 | 0.002 |
| Liver cirrhosis (yes vs. no) | 2:43 | 8:22 | 0.012 |
| > 80 % adherence (yes vs. no) | 32:13 | 21:9 | 0.918 |
| rs12979860 (CC vs CT + TT) | 43:2 | 20:10 | 0.002 |
| rs 8099917 (TT vs GG + GT) | 45:0 | 20:10 | < 0.001 |
| TLR2 mRNA (median,IQR) | −1.07 (−4.05 ~ −0.74) | −0.96 (−3.39 ~ −0.67) | 0.304 |
| TLR3 mRNA (median,IQR) | −3.39 (−4.53 ~ −2.86) | −3.28 (−4.10 ~ −2.90) | 0.607 |
| TLR4 mRNA (median,IQR) | −1.24 (−4.05 ~ −0.96) | −1.02 (−3.54 ~ −0.78) | 0.067 |
| TLR7 mRNA (median,IQR) | −2.76 (−4.53 ~ −2.19) | −2.42 (−4.18 ~ −2.20) | 0.545 |
| TLR9 mRNA (median,IQR) | −2.85 (−4.57 ~ −2.59) | −2.62 (−4.12 ~ −2.47) | 0.124 |
RVR rapid virological response, BMI body mass index, ALT alanine aminotransferase, TLR toll like receptor. TLR mRNA expression levels were shown as log ratios relative to GAPDH mRNA (log 2 -(∆Ct))