. 2016 Jul 26;14:109. doi: 10.1186/s12955-016-0512-9

Table 3.

Between-group differences and baseline adjustment when analyzing QoL measures among patients with AS

	Quality of life						Heart function		Status of assistance
	EQ-5D_Index	five EQ-5D dimensions
	(1)	(2)	(3)	(4)	(5)	(6)	(7)	(8)	(9)
	EQ-5D_Index	Mobiliy	Looking after myself	Doing usual activities	Having pain or discomfort	Feeling worried, sad or unhappy	NYHA score	CCS score	Status of assistance
	Point estimate	Odds ratios from the ordered logistic regression model
Value at baseline	0.321^***	7.314^***	18.30^***	9.356^***	2.222^***	2.756^***	2.419^***	1.378^***	9.049^**
EuroSCORE at baseline	−0.000761	1.029	1.046	1.040^*	0.999	1.011	0.992	1.000	0.985
TAVR	Reference	Reference	Reference	Reference	Reference	Reference	Reference	Reference	Reference
SAVR	0.0532	0.209^**	0.754	0.396^*	0.459^**	0.413^*	1.258	0.912	0.0441^***
SAVRplus	−0.112^*	3.162	6.843	3.559	2.185	2.487	2.416	1.132	1.129
DRUG	−0.180^**	14.42^***	1.463	1.948	2.114	3.667^***	26.69^***	1.416	2.174
Last follow-up before death	−0.536^***	111.5^***	291.0^***	149.0^***	34.40^***	53.33^***	4.141	1.816	123.2^**
Second last follow-up before death	−0.334^***	16.37^**	31.55^***	8.390^*	19.85^***	16.00^***	1.826	1.752	16.09^*
Third from last follow-up before death	−0.246^***	15.48^*	30.99^***	9.799^*	3.929	3.782	5.026^*	1.817	55.18^**
Fourth from last follow-up before death	−0.225^***	9.108^*	12.66^***	7.110	4.175	8.558^**	1.670	2.307	24.06^**
Fifth from last follow-up before death	−0.157^***	6.018	15.68^**	11.47^*	1.822	2.491	0.985	1.371	16.51^*
Sixth from last follow-up before death	−0.108^**	2.088	3.711	3.231	3.290	3.457	1.360	1.129	16.89
Overall trend	−0.00140	1.087^***	1.041	0.967	1.043^***	0.978	1.051^***	1.021	1.071^*
Month 1 post-discharge	−0.0425^**	2.139^*	2.038^*	2.282^**	1.212	1.346	1.853^*	1.047	3.206^*
Constant	0.554^***
N	2159	2189	2193	2191	2191	2156	2119	1952	1317

^* p < 0.05, ^** p < 0.01, ^*** p < 0.001

The EQ-5D_Index is a continuous variable between 0 and 1 (0 = worst state, 1 = best state). The 5 EQ-5D dimensions as shown in Model (2) to model (6) are order categorical variables (1 = no problems, 2 = some problems, 3 = extreme problems). Canadian Cardiovascular Society (CCS) Angina Grading Scale is an order categorical variable between 1 (angina only during strenuous or prolonged physical activity) and 4 (inability to perform any activity without angina). New York Heart Association (NYHA) Functional Classification is an order categorical variable between 1 (cardiac disease, but no symptoms and no limitation in ordinary physical activity) and 4 (severe limitations, experiences symptoms even while at rest). The current state of assistance is an order categorical variable with 1 (no external help or intra-familial help only), 2 (assisted living and/or home care services) and 3 (short or long-term care or temporal hospitalization). The group SAVRplus includes 17 patients that underwent additional bypass grafting and/or mitral valve replacement