. 2016 Jul 26;14:109. doi: 10.1186/s12955-016-0512-9

Table 4.

Impact of clinical events on QoL measures among TAVR and SAVR patients

	Quality of life						Heart function		Status of assistance
	EQ-5D_Index	Five EQ-5D dimensions
	(1)	(2)	(3)	(4)	(5)	(6)	(7)	(8)	(9)
	EQ-5D_Index	Mobility	Looking after myself	Doing usual activities	Having pain or discomfort	Feeling worried, sad or unhappy	NYHA score	CCS score	Status of assistance
	Point estimate	Odds ratios from the ordered logistic regression model
Value at baseline	0.350^***	14.19^***	34.09^***	10.96^***	1.671^*	2.751^***	2.457^***	1.398^***	10.82^**
ASB life threatening/disabling	−0.0463	12.68^**	0.680	0.199	2.860	0.771	0.123	0.188	0.104
ASB major/minor	0.0985^*	0.587	0.499	0.201^**	0.182^*	0.121^*	0.762	0.673	0.342
NASB life threatening/disabling	−0.447^***	584.6^**	54.93	7.752	0.739	47.86^*	1.410	1.591	86.32^*
NASB major/minor	−0.0199	1.188	0.688	0.597	1.311	0.573	1.180	0.813	4.088
VASC major/minor	−0.00695	0.282	0.971	2.029	0.833	2.110	1.422	0.660	6.198
Stroke/TIA	−0.161^*	8.298^**	1.358	4.179	6.661	2.561	0.343	0.380	0.958
AKIN 1	0.0659	1.270	1.104	0.357	0.430	0.742	0.547	0.601	0.718
AKIN 2	−0.158^*	1.297	7.126	102.2^**	0.814	0.340	81.36^*	104.2^**	21.79
AKIN 3	−0.177^**	15.75^***	21.53^**	7.419^*	2.908	3.495	1.243	1.404	1.955
Arrhythmia	−0.0377	2.393	3.153	1.954	1.817	2.200	3.490	0.234^*	1.270
Other complications	0.0330	2.617	0.933	0.457	0.366	0.402	1.380	5.237^*	1.057
Last follow-up before death	−0.493^***	81.93^***	154.9^***	48.14^**	29.90^***	32.98^***	2.877	1.335	144.8^**
Second last follow-up before death	−0.270^***	11.50^**	23.04^***	5.949	15.13^***	11.13^***	1.542	1.786	12.95
Third from last follow-up before death	−0.204^***	8.142	17.64^**	4.509	1.996	3.602	3.855^*	1.377	66.29^**
Fourth from last follow-up before death	−0.176^***	7.797^*	11.09^**	5.952	2.471	7.750^**	1.581	2.016	23.22^*
Fifth from last follow-up before death	−0.150^***	4.843	13.36^**	8.091	1.600	2.446	0.926	1.217	25.23^*
Sixth from last follow-up before death	−0.104^*	1.800	3.205	2.907	3.803	2.932	1.259	1.081	35.30^*
Overall trend	−0.00165	1.085^***	1.045	0.966	1.044^***	0.983	1.056^***	1.020	1.088^**
Month 1 post-discharge	−0.0233	1.602	1.433	2.066^*	1.465	1.130	1.370	1.599	2.774
Constant	0.528^***
N	2212	2246	2256	2254	2254	2219	2182	2022	1357

^* p < 0.05, ^** p < 0.01, ^*** p < 0.001

The EQ-5D_Index is a continuous variable between 0 and 1 (0 = worst state, 1 = best state). The 5 EQ-5D dimensions as shown in Model (2) to model (6) are order categorical variables (1 = no problems, 2 = some problems, 3 = extreme problems). Canadian Cardiovascular Society (CCS) Angina Grading Scale is an order categorical variable between 1 (angina only during strenuous or prolonged physical activity) and 4 (inability to perform any activity without angina). New York Heart Association (NYHA) Functional Classification is an order categorical variable between 1 (cardiac disease, but no symptoms and no limitation in ordinary physical activity) and 4 (severe limitations, experiences symptoms even while at rest). The current state of assistance is an order categorical variable with 1 (no external help or intra-familial help only), 2 (assisted living and/or home care services) and 3 (short or long-term care or temporal hospitalization). ASB access site bleeding, NASB non-access site bleeding, VASC vascular complication, AKIN acute kidney injury