. 2016 Jul 26;14:109. doi: 10.1186/s12955-016-0512-9

Table 5.

Impact of clinical events on EQ-5D_Index among AVR patients accounting for time-to-death

	Time-to-death adjustment (six months)		Exclusion of cases of mortality (six months prior to death)		EQ-5D_Index = 0 in month of death
	(1)	(2)	(3)	(4)	(5)	(6)
	EQ-5D_Index	EQ-5D_Index	EQ-5D_Index	EQ-5D_Index	EQ-5D_Index	EQ-5D_Index
Value at baseline	0.348^***	0.346^***	0.333^***	0.331^***	0.333^***	0.331^***
ASB life threatening/disabling	−0.0593	−0.140^*	0.0356	−0.0497	−0.0599	−0.121
…at the second follow-up after event		−0.145^*		−0.155^*		−0.0993
…at the third follow-up after event		−0.163^**		−0.0950		−0.145^*
NASB life threatening/disabling	−0.449^***	−0.493^***	−0.457^***	−0.508^***	−0.448^***	−0.465^***
…at the second follow-up after event		−0.114		−0.140		−0.101
…at the third follow-up after event		0.103		0.0936		0.109
Stroke / TIA	−0.147^*	−0.206^**	−0.145^*	−0.210^**	−0.147^*	−0.199^*
…at the second follow-up after event		−0.123		−0.146^*		−0.121
…at the third follow-up after event		−0.0319		−0.0286		−0.0307
AKIN 2	−0.167^*	−0.226^**	−0.267^**	−0.270^**	−0.169^*	−0.272^**
…at the second follow-up after event		−0.142		−0.0428		−0.195^*
…at the third follow-up after event		0.0657		0.0150		0.0508
AKIN 3	−0.173^**	−0.186^**	−0.235^**	−0.293^***	−0.381^***	−0.418^***
…at the second follow-up after event		−0.113		−0.177^*		−0.235^**
…at the third follow-up after event		−0.00684		−0.0338		−0.0939
Other complications	0.00548	0.00571	0.0134	0.0140	0.00464	0.00368
Last follow-up before death	−0.493^***	−0.487^***
Second last follow-up before death	−0.275^***	−0.272^***
Third from last follow-up before death	−0.210^***	−0.217^***
Fourth from last follow-up before death	−0.180^***	−0.189^***
Fifth from last follow-up before death	−0.154^***	−0.166^***
Sixth from last follow-up before death	−0.108^**	−0.116^**
Overall trend	−0.00161	−0.00222^**	−0.00195^*	−0.00249^**	−0.00322^***	−0.00386^***
Month 1 post-discharge	−0.0230	−0.0283	−0.0256	−0.0301	−0.0163	−0.0218
Constant	0.529^***	0.543^***	0.548^***	0.559^***	0.508^***	0.523^***
N	2212	2212	2102	2102	2250	2250

^* p < 0.05, ^** p < 0.01, ^*** p < 0.001

The EQ-5D_Index is a continuous variable between 0 and 1 (0 = worst state, 1 = best state). ASB access site bleeding, NASB non-Access Site Bleeding, VASC vascular complication, AKIN acute kidney injury. Please note that we also increased these time lags up to 6 months after complications but found no additional effects