Table 3.

Model A: logistic regression investigating an association between placental DNA methylation and GDM; model B: logistic regression investigating an association between placental DNA methylation grouped into the fifth quintile (n = 206) versus quintiles 1–4 (n = 824) and GDM

Model A Constant −8.647 ± 1.589; p < 0.0001	B	S.E.	Sig.	Exp(B)	95 % CI for Exp(B)
					Lower	Upper
Maternal age, years	0.061	0.026	0.017	1.063	1.011	1.118
BMI beginning of pregnancy, kg/m2	0.067	0.025	0.008	1.069	1.018	1.124
S/p 2 or more miscarriages, %	−0.128	0.502	0.798	0.880	0.329	2.351
Ethnicity (Caucasian, other)	−0.111	0.558	0.842	0.895	0.300	2.669
Diabetes in family (yes/no)	−0.318	0.289	0.271	0.728	0.413	1.281
Placental DNA methylation, %	0.879	0.267	0.001	2.408	1.427	4.063
Model B Constant −5.240 ± 1.275; p < 0.0001	B	S.E.	Sig.	Exp(B)	95 % CI for Exp(B)
					Lower	Upper
Maternal age, years	0.061	0.026	0.017	1.063	1.011	1.118
BMI beginning of pregnancy, kg/m2	0.073	0.025	0.004	1.076	1.024	1.13
S/p 2 or more miscarriages, (%)	−0.143	0.501	0.775	0.867	0.325	2.314
Ethnicity (Caucasian, other)	−0.139	0.554	0.802	0.87	0.294	2.579
Diabetes in family (yes/no)	−0.314	0.289	0.277	0.731	0.415	1.286
Placental DNA methylation (grouped)	1.098	0.292	0.0002	2.999	1.691	5.316