Table 2.

Description of the studies included

Author	Year	Country	Population	Exclusion	Specie	Time
Özgöztaslis O [19]	1997	Turkey	Patients between 2–50 years seen in a medical center; mean of 12.	Sickness that is exacerbated by the cold, infected lesions and pregnant or nursing women	Leishmania spp.	6 months
Gurei M [22]	2000	Turkey	Patients with a confirmed parasitological diagnosis	N.E.	N.E	3 months
Asilian A [21]	2004	France	Patients from the Leishmania and Skin diseases Research Center. Age ranged 2–65 years, mean of 26.	Lesions > 2 months (to exclude any natural self-healing during follow-up), allergy to antimonials, those pregnant and breastfeeding	L. tropica/L. major	6 months
Salmanpour R [15]	2006	Iran	Patients attending the dermatological unit of the Faghihi Hospital, Shiraz	N.E.	Leishmania spp.	≥2 months
Layegh P [10]	2009	Iran	Patients ≤ 13 years from the Dermatological Clinic of the Qaem Hospital, Mashad. Age mean 6.8 ± 3.4 in cruytherapy and 6.2 ± 3.4 in Glucantime	Lesions ≥ 3 months, allergy to antimonials, patients who utilized another treatment at the beginning of the study	Leishmania spp.	6 months
López P [20]	2010	Colombia	Patients < 10 years from local hospitals in Santander and Tolima. 38.8 % women and 61.2 % men.	Use of anti-Leishmania drugs in the last 3 months, > 5 lesions, lesions on the border (<2 cm) of mucosal areas, eyes, nose, mouth or genitals	Leishmania (V.) panamensis	3 months
Negera E [14]	2012	Ethiopia	Patients from the Kibet Health Center. Age mean 18.4 ± 11.7 in cryotherapy and 19.6 ± 7.4 in SSG	N.E.	Leishmania aethiopica	6 months
Soto J [13]	2013	Bolivia	Patients > 12 years from the province of Chapare, Bolivia	Lesions > 30 mm, use of anti-Leishmania therapy in the last 3 months, history of concomitant diseases, mucosal lesions in the nose and mouth and immunosuppression	L. braziliensis	6 months

N.E. The article does not give explicit information about this variable